Bioengenharia
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Item Estudo do microrelevo cutâneo após o uso da dermaplanagem por meio da fotogrametria digital tridimensional(Universidade Brasil, 2021) Ventura, Danielle Bastos da Silva; Frade-Barros, Amanda FarageThe skin surface is a barrier and can selectively communicate with the internal biological environment and the external environment, it is not flat and contains several straight grooves that can be classified according to depth, and therefore, these conditions that define its micro relief are related to its exchanges and its breathing, so the photogrammetric analysis instruments allow its amplification, making it possible and necessary to describe them. Dermaplaning is a technique used in qualified aesthetic protocols, facial rejuvenation and the treatment of atrophic scars, based on the concept of physically removing the superficial layers of the skin by dragging a blade of sterile, disposable butter from a scalpel. The three-dimensional photogrammetry analysis instruments are modern resources of current tissue bioengineering and allow a form of tissue enlargement in a precise and non-invasive way. Two dermaplaning intervals with 21-day intervals were performed in women between 18 and 38 years old, divided into 2 groups (control n = 21, test n = 21) with complaints of skin texture alteration. The effectiveness of the treatment was evaluated using three-dimensional digital photogrammetry and photothermographic imaging before and after the preparations. The group showed decreased oiliness, local hydration and increased count of elastic and collagen fibers, as well as surface pigmentation, through arbitrary measures provided by the equipment. This study was of fundamental importance to verify, in addition to the changes in the biotype, that there were topographic changes in the cutaneous microrelief after the use of dermaplaning and showed that the technique is a possible effective dermatological or aesthetic therapy to improve the microrelief, but it is necessary its post-procedure skin management.Item Luz UV-C na descontaminação de diferentes superfícies(Universidade Brasil, 2021) Soares, Roseane Débora Barbosa; Baptista, AlessandraItem A suplementação de vitamina C inibe hiperativação de células de Leucemia Mielóide Crônica induzidas por Lipopolysaccarídeo: envolvimento da sinalização purinérgica(Universidade Brasil, 2021) Pires, Daniela Alves; Vieira, Rodolfo de PaulaChronic myeloid leukemia (CML) is a myeloproliferative neoplasm, characterized by overproduction of white blood cells, with the patients presenting anemia, fatigue, infections, bleeding, and other problems. Thus, an important goal for CML patients is to prevent infections and inhibit the exacerbation of inflammatory processes. In this context, the present study investigated whether vitamin C could inhibit hyperinflammatory activation of K562 cells induced by LPS and whether purinergic signaling is involved in such response. Two doses of vitamin C were used (5 µg/mL and 10 µg/mL) for 2 hours prior LPS (10ng/mL) for 22 hours in K-562 cells (3x105 cells/mL/well). The results demonstrated that both doses of vitamin C significantly reduced LPS-induced the release of IL-6 (5 µg/mL, p<0.01 and 10µg/mL p<0.01) and TNF-alpha (5 µg/mL, p<0.01 and 10µg/mL p<0.01). In contrast, both doses of vitamin C induced the release of the anti-inflammatory cytokine IL-10 (5 µg/mL, p<0.01 and 10µg/mL p<0.01). In addition, 10µg/mL of vitamin C induced the release of klotho(10µg/mL p<0.01), an anti-aging and antiinflammatory protein. Importantly, vitamin C (5 µg/mL, p<0.01 and 10µg/mL p<0.01) reduced ATP release and accumulation in the extracellular milieu as well as reduce the expression at mRNA levels of P2X7 receptor, suggesting a possible mechanism of action. Therefore, we conclude that vitamin C inhibits hyperinflammatory state induced by LPS in K-562 cells involving purinergic signaling.Item Dermatite induzida por produtos de higiene das mãos no contexto da pandemia de Covid-19(Universidade Brasil, 2021) Almeida, Amanda Priscila; Navarro, Ricardo Scarparo; Nuñez, Silvia CristinaThe COVID-19 pandemic ravaged the entire planet and important behaviors were reinforced by all health control agencies around the world, such as social distancing, the use of protective masks and hand hygiene, through washing with water and soap or application of alcohol gel. The aim of this study was to carry out an integrative review of the evidence in the literature on the characteristics of dermatitis induced by hand hygiene products in the context of the COVID-19 pandemic and to carry out a survey of information through a structured questionnaire on the behavior of the population and the hand hygiene care during 2020. An integrative review of articles was carried out, following the PICOS strategy, in Portuguese, English and Spanish, between December 2019 and April 2021, with the descriptors: contact dermatitis; hand dermatitis; hand disinfection; occupational dermatitis; occupational irritant hand dermatitis AND COVID-19; coronavirus; pandemic; pandemic; SARS-COV-2 with their corresponding terms in Portuguese and Spanish. The Boolean OR operator was applied between the terms. The search was performed in PubMed, MEDLINE, LILACS and Scielo databases. An electronic form was made available online to answer questions related to hand hygiene and cleaning habits within the context of the COVID-19 pandemic. According to the results, from the search for studies and with double and triple crossings, 557 articles were found, among these, 24 articles were selected related to the study topic. The answers to the questions were converted into numbers and the normality of the distribution of variables was tested using the Shapiro-Wilk test. The data obtained were analyzed by Student's t and Wilcoxon statistical tests and correlation analyzes were performed using the Pearson's Correlation Coefficient using the SPSS software (IBM SPSS Statistics for Windows, version 25.0.; IBM, Armonk, New York) in the interval 95% confidence. A total of 1027 responses to the questionnaire were obtained and it was observed that 21.4% of the participants had COVID-19 and 93% changed their hand hygiene habits after the pandemic, the habit of using alcohol gel was one of the biggest changes (83.1 %), 52.2% of the participants learned something new about cleaning their hands after the pandemic and 74.6% noticed a change in the skin on their hands after the onset of the pandemic. Among those interviewed, 8% had to seek medical help for problems with the skin on their hands. We can conclude that education measures on hand hygiene habits should persist as important public health actions and the quality of products used for hand hygiene should be a factor to be considered both by establishments that provide hygiene products and by purchased products by the users.