Engenharia Biomédica
URI permanente para esta coleçãohttps://repositorioacademico.universidadebrasil.edu.br/handle/123456789/33
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Resultados da Pesquisa
Item Uso da Ozonioterapia em fungos causadores de Onicomicoses: estudo in vitro(Universidade Brasil, 2024) Del Castilo, Denise Vivianni Ferreira; Assis, Lívia; Tim, Carla Roberta: Onychomycosis is a common fungal infection of the nails, predominantly caused by dermatophytes such as Trichophyton rubrum (T. rubrum) and Microsporum gypseum (M. gypseum) and is a notoriously difficult condition to treat. Thus, the objective of the present study was to evaluate and compare, in vitro, the effectiveness of different times of ozone therapy on the main fungi that cause onychomycosis. Dermatophyte fungi T. rubrum (ATCC 28188) and M. gypseum (ATCC 24102) were incubated at 28° C for 14 days. Subsequently, the fungi were divided into 9 experimental groups according to the experimental time: Control Group (CG): the fungi were cultivated and did not receive any treatment; Cultivated fungi and received ozone therapy for a time of 2 min (G2”); 4 min (G4”); 6 min (G6”); 8 min (G8”); 10 min (G10”); 12 min (G12”); 14 min (G14”) and 16 min (G16”). The ozone concentration used was 2 µg/mL, oxygen flow of 1/4 L/min and applied dosages of 157, 314, 451, 628, 785, 943, 1100 and 1257 mg/m2, respectively. The main results show that the use of topical ozone therapy was effective in reducing the germination percentage of T. rubrum and M. gypseum in all experimental periods, presenting complete eradication with a treatment time of 6 min for T. rubrum and 14 min for M. gypseum. In conclusion, ozone therapy used topically, with emphasis on the treatment time of 6 min for T. rubrum (628 mg/m2) and 14 min (1257 mg/m2) for M. gypseum, promoted antifungal action on the main dermatophytes responsible for critical complications of onychomycosis, and may be proposed as a adjuvant in dermatological treatments.Item Ozonioterapia associada a um protocolo de exercício físico na dor e funcionalidade de indivíduos com osteoartrite de joelho: ensaio clínico controlado e randomizado(Universidade Brasil, 2022) Rezzo, Thiago Correia da Silva; Garcia, Lívia Assis; Tim, Carla RobertaKnee osteoarthritis (KOA) is a degenerative joint disease that causes pain, impairment of function and quality of life and is associated with significant economic impact. Ozone therapy (OT) has been suggested in clinical practice as a promising adjuvant therapy to exercise, however evidence is limited for its recommendation. Thus, the aim of this study was to evaluate the effects of OT in combination with an exercise protocol on pain level in women with KOA. Forty volunteers were randomized into 2 groups: Exercise Group (EG): volunteers were submitted to a physical exercise protocol; Ozone Therapy Exercise Group (GEO): volunteers were submitted to a resistance exercise protocol associated with OT. The interventions were performed twice a week for a period of 6 weeks, totaling 12 sessions. The exercise program consisted of warm up, muscle strengthening, and stretching of the main muscle groups of the lower limbs. OT was applied to 5 acupuncture points of the affected knee, through the subcutaneous technique at a concentration of 20 g/ml and with a volume of 2 mL of ozone immediately after each exercise session. For evaluation and reevaluation, the numerical pain scale (NDS) was applied; functionality and quality of life questionnaires (Western Ontario and MacMaster Universities Osteoarthritis Index [WOMAC]); functionality (Lequesne); physical performance tests (Timed Up and Go [TUG], Short Physical Performance Battery [SPPB]), lower limb strength and endurance (30-second sit and stand test). The results show that the GE and GEO groups presented lower scores for the level of pain, increased the score of quality of life, functionality, physical performance, strength and resistance compared to the initial values. However, GEO had a lower score for the level of pain, and a higher score for quality of life and functionality when compared to GE. Thus, it can be suggested that OT in association with physical exercise was an effective method in pain control and in the functional recovery and quality of life of patients with KOA.Item Ozonioterapia associada a um programa de exercício na dor e incapacidade de indivíduos com dor lombar crônica: ensaio clínico controlado e randomizado(Universidade Brasil, 2022) Silva, Rafael Basatos; Garcia, Lívia Assis; Tim, Carla RobertaChronic low back pain (CLBP) is one of the most common musculoskeletal disorders, prevalent worldwide and one of the main causes of disability and damage to quality of life, representing a significant economic burden. Ozone therapy (OT) has been suggested in clinical practice as an adjuvant therapy to physical exercise, however the evidence is limited for its recommendation. Thus, the aim of this study was to evaluate the effects of OT in combination with a physical exercise protocol on pain level in subjects with chronic low back pain. Forty-two volunteers were randomized into 2 groups: Control group (Ex): volunteers underwent a physical exercise protocol; Ozone Therapy Exercise Group (ExOT): volunteers underwent a resistance physical exercise protocol associated with OT. Interventions were performed twice a week for a period of 6 weeks, totaling 12 sessions. The exercise program consisted of exercises that strengthened, stretched, mobilized, coordinated and stabilized the abdominal, lumbar, pelvic and lower limb muscles. OT was applied at 5 points on the paravertebral muscles, bilaterally, totaling 10 points, through the intramuscular technique at a concentration of 20 g/ml and with a volume of 2 mL of ozone right after each proposed exercise session. For assessment and reassessment, the Numerical Pain Scale (END) was applied; disability index (Oswestry Disability Index); flexibility test (Third finger to floor test); trunk flexion/extension mobility test (Gonimetry); kinesiophobia (Kinesiophobia Cap Scale); emotional state (Anxiety Numerical Scale - ENA) and assessment of the perception of the global effect (Global Effect Perception Scale - EPEG). The results showed that both the Ex and the ExOT groups had a lower pain level, lower scores in disability tests, improved flexibility, lower scores in kinesiophobia when compared to the initial values. However, the lowest scores for the level of pain, disability and the highest scores for the level of perception of recovery were evidenced in the ExOT group. Thus, it can be suggested that OT associated with the physical exercise program was a more effective method in reducing pain and functional disability in the treatment of CLBP.Item Uso de um gerador de ozônio de volume controlado na adiposidade localizada abdominal: ensaio clínico controlado e randomizado(Universidade Brasil, 2024) Silva, Fabiele Chieregato Marchetti da; Garcia, Lívia Assis; Tim, Carla RobertaOzone therapy has been suggested in clinical practice as a promising and adjuvant therapy in the minimally invasive treatment of localized adiposity; however, evidence is limited for its recommendations. Thus, the aim of the study was to evaluate the safety and efficacy of a controlled-volume ozone generator at different dosages in localized abdominal adiposity. To achieve this objective, a single-center randomized controlled clinical trial was conducted. Female participants were recruited and 110 were randomized into 4 groups: Sham Group (GS): participants received treatment with the ozone equipment turned off; Intervention Groups: participants received ozone treatment at doses of 20 (G20), 30 (G30), and 40 g/ml (G40). The interventions were performed at 24 pre-established points in the abdominal region, twice a week for a period of 4 weeks, totaling 8 sessions. The initial assessment (A1) and reassessment [15 (A2) and 30 (A3) days after the last session] were performed through anthropometric analyses, bioimpedance, abdominal circumference, adipometry, global aesthetics (GAIS), adipose tissue thickness through diagnostic ultrasound, recording of patient satisfaction assessment (Linkert) and adverse effects. The main results show that groups G20, G30 and G40 presented a reduction in abdominal circumference in the periods of 15 and 30 days after treatment, lower GAIS score and improvement in the treatment satisfaction score in both periods evaluated. However, G40 presented lower adipose tissue thickness in both experimental periods. No serious adverse effects were reported. Thus, it can be suggested that the controlled volume ozone generator used in the present study proved to be a safe and potentially promising modality in the treatment of localized adiposity, with emphasis on the dose of 40 ug/ml.