Bioengenharia
URI permanente para esta coleçãohttps://repositorioacademico.universidadebrasil.edu.br/handle/123456789/31
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Resultados da Pesquisa
Item Avaliação dos efeitos da auriculoterapia e auriculoterapia a laser no tratamento das alterações de olfato e paladar pós Covid-19 - estudo clínico(Universidade Brasil, 2023) Oliveira, Andreia de; Navarro, Ricardo Scarparo; Baptista, AlessandraCOVID-19 is an infectious disease caused by the new coronavirus, also known as severe acute respiratory syndrome virus 2 (SARS-CoV-2). There are characteristic systemic changes during the disease process, and post-COVID-19, called long COVID, we can highlight the sensory changes in smell and taste that directly interfere with individuals' quality of life. The objective of the study was to evaluate the effects of auriculotherapy (AT) and laser auriculotherapy (LAT) in the treatment of post-COVID- 19 changes in smell and taste. After approval by the CEP (5,357,603), acceptance and signing of the TCLE by the participants, with a positive PCR exam or self-test for COVID-19, treated, aged over 18 years, of both sexes, were randomly divided into groups : G1 (AT) (n=12) AT with mustard seeds; G2 (LAT) (n= 12) AT with low power laser (Laser Duo, MMOptics, São Carlos, Brazil) (808 nm, 3 J, 100 mW, 30 s, tip area 0.03 cm2, 3.33 W/cm2, 100 J/cm2); G3 (LAT placebo) (n= 12) LAT as in group 2, with a barrier at the exit of the laser beam emission; G4 (LAT tip) (n= 12) as in group 2, using acupuncture tip (808 nm, 3 J, 100 mW, 30 s, tip area 0.07 cm2, 1.43 W/cm2, 42.9 J/cm2) (MMOptics, São Carlos, Brazil). In all groups, AT was performed in contact with the skin on the ear at different acupoints (Shen Men, Kidney, Sympathetic, Tongue, Mouth, External Nose, Internal Nose/Pharynx, Heart, Lung), once a week, totaling 10 sessions. Participants were evaluated by anamnesis, Sensory Assessment Tests (SAT) of Smell and Taste before and after each session. The results showed for SAT smell and taste in the intragroup analysis in G1-AT, G2-LAT and G4-LAT tip there was a significant difference before and after treatments (p<0.05), in G3-LAT placebo smell there was no difference for sweet and salty (p>0.05) and there was a difference for bitter, sour, spicy (p>0.05); in G3-LAT placebo taste there was no significant difference (p>0.05) for all variables. For the intergroup analysis for SAT smell and taste: between the auriculotherapy groups (G1 AT, G2 LAT, G4 LAT tip) and G3 LAT placebo there were significant differences (p<0.05), between the auriculotherapy groups they were no differences (p>0.05) and the treatments promoted an effective increase in smell and taste values (p<0.05), the G3 LAT placebo group presented lower results than the treatments groups. It can be concluded that auriculotherapy and laser auriculotherapy were effective in treating changes in smell and taste after COVID-19; the different modalities of auriculotherapy - AT, LAT, LAT tip promoted recovery of smell and taste, with no differences between treatments; there were no placebo effects, the study proposes new therapeutic protocols of auriculotherapy and laser auriculotherapy in the treatment of changes in smell and taste after COVID-19; no side effects, non- pharmacological, non-invasive, painless, with greater patient acceptability.Item Estudo do microrelevo cutâneo após o uso da dermaplanagem por meio da fotogrametria digital tridimensional(Universidade Brasil, 2021) Ventura, Danielle Bastos da Silva; Frade-Barros, Amanda FarageThe skin surface is a barrier and can selectively communicate with the internal biological environment and the external environment, it is not flat and contains several straight grooves that can be classified according to depth, and therefore, these conditions that define its micro relief are related to its exchanges and its breathing, so the photogrammetric analysis instruments allow its amplification, making it possible and necessary to describe them. Dermaplaning is a technique used in qualified aesthetic protocols, facial rejuvenation and the treatment of atrophic scars, based on the concept of physically removing the superficial layers of the skin by dragging a blade of sterile, disposable butter from a scalpel. The three-dimensional photogrammetry analysis instruments are modern resources of current tissue bioengineering and allow a form of tissue enlargement in a precise and non-invasive way. Two dermaplaning intervals with 21-day intervals were performed in women between 18 and 38 years old, divided into 2 groups (control n = 21, test n = 21) with complaints of skin texture alteration. The effectiveness of the treatment was evaluated using three-dimensional digital photogrammetry and photothermographic imaging before and after the preparations. The group showed decreased oiliness, local hydration and increased count of elastic and collagen fibers, as well as surface pigmentation, through arbitrary measures provided by the equipment. This study was of fundamental importance to verify, in addition to the changes in the biotype, that there were topographic changes in the cutaneous microrelief after the use of dermaplaning and showed that the technique is a possible effective dermatological or aesthetic therapy to improve the microrelief, but it is necessary its post-procedure skin management.Item A relação entre a irradiação transcutânea do sangue – ILIB modificada e os níveis de cortisol salivar em cuidadores de idosos saudáveis(Universidade Brasil, 2021) Trindade, Monaiza Moura; Baptista, AlessandraFormal caregivers usually have exhaustive work scale that can trigger emotional changes and a decrease in the quality of life of these professionals. The use of ILIB (Intravascular Laser Irradiation of Blood) can improve the immunological activity of the blood, in addition to facilitating blood circulation and has been used in the treatment of different diseases. The aim of this study was to verify the effects of ILIB, applied transcutaneous, in relation to the levels of salivary cortisol of caregivers of formal elderly in long-term care institutions, who work during the day and night. Forty-two caregivers of formal elderly people were divided into 6 groups: Day Group (DG) (n=7); Day ILIB Group (DILIBG) (n=7); Day ILIB/placebo group (DPG) (n=7); Night Group (NG) (n=7); ILIB Night Group (NILIBG) (n=7); and Night ILIB/placebo Group (NPG) (n=7). Volunteers in the ILIB and ILIB / placebo groups received ILIB, in the radial artery region, by means of a low-power laser (Laser Duo, MMOPTICS, São Carlos, Brazil), l= 660 nm, P = 100 mW / 30 min, every other day, for 2 weeks, totaling 8 sessions of treatment/placebo, while the groups: GD and GN performed salivary collection on the day off and on the workday. All participants answered the quality of life questionnaire (QLQ) before any procedure and saliva collections for volunteers in the ILIB and ILIB/placebo groups were performed before any procedure; 24 h and 48 h after 8 treatment/placebo sessions, while the groups: DN and NG performed salivary collection on the day off and on the workday. The QLQ results did not show statistically significant differences between daytime and nighttime workers (p>0.05). Regarding cortisol quantification, the results showed statistically significant decreases (p<0.05) in salivary cortisol levels, both in the ILIB groups and in the placebo groups. Therefore, we can conclude that it was possible to measure the salivary cortisol levels of caregivers of formal elderly in long-stay institutions, who work day and night, treated or not with ILIB. However, ILIB cannot help to reduce salivary cortisol levels in caregivers of elderly people in long-term care facilities.Item Luz UV-C na descontaminação de diferentes superfícies(Universidade Brasil, 2021) Soares, Roseane Débora Barbosa; Baptista, AlessandraItem Implementação de um software/aplicativo para avaliação das escolhas alimentares(Universidade Brasil, 2021) Silva, William Santos; Barros, Amanda Farage FradeThe dietary choices of each individual is developed based on the intrinsic and extrinsic factors that influence their lives, so due to several changes in the lifestyle of the criteria their choices for certain eating habits can generate losses in the long term, such as the development of chronic diseases non-transmissible. In this context, the development of a software, in Portuguese, using the Food Choice Questionnaire (FCQ) validated instrument can facilitate the evaluation of the choice of food preferences. This research aims to develop a software to analyze the aspects that influence food choices, in addition to validating the software by nutritionists and health professionals. The application “Minhas Escolhas Alimentares” was developed in the JAVA programming language using the Object-Oriented Programming methodology, available in technology Android. For the creation of the “Minhas Escolhas Alimentares” App, was based in the validated questionnaires, Food Choice Questionnaire (FCQ), and on the Food Guide for the Brazilian Population. Healthcare professionals (n = 30) participated in the usability test of the application by collecting information through the QUIS test and statistical treatment of the data. Based on the results, it was possible to confirm the broad approval of the Minhas Escolhas Alimentares App. The development of the software was successfully developed, considering the specifications for compatibility with Android technology. Therefore, the software developed will be of great importance for the better monitoring and evaluation of the adult and elderly public, being able to infer the impact on their quality of life, as well as assist in the work of health professionals in the nutrition field such as nutritionists, nutrologists, pharmacists , endocrinologists and others, to better target their patients' food choices. The application is already available in the Google Play store for free, allowing its use in universities, research centers, clinics and hospitals.Item Avaliação dos efeitos da desinfecção química e com radiação ultravioleta na estabilidade dimensional de diferentes materiais de moldagem odontológicos(Universidade Brasil, 2021) Santos Neto, Antonio Vinicios dos; Navarro, Ricardo ScarparoThe disinfection of molds obtained with dental impression materials is within the biosafety protocols, in the control of cross-infection of microorganisms in dental offices, prosthesis laboratories, professionals and patients, being currently the target of greater attention due to the pandemic of COVID-19, with the implementation of alternative disinfection protocols and methods. The purpose of this study was to compare the effects of disinfection by ultraviolet radiation and chemical disinfection on dimensional stability of different dental molding materials. Acrylic resin mannequin molds with irreversible hydrocolloidal materials (alginate) (n = 25) and elastomer (condensation silicone) (n = 25) were used with different disinfection methods (n = 5): G1- negative control: no treatment, G2- Glutaraldehyde 2% (10 min), G3- Sodium hypochlorite 1% (10 min), G4- UV-C radiation (λ = 254 nm) (30 s), G5- Autoclave (positive control) (15 min). The molds after the treatments were cast with special plaster. After 24 h, the plaster models were measured by a calibrated, blinded researcher, with a caliper in determined places on the upper first molar: mesio-distal (MD-O) and vestibulo-lingual (VL-O) and buccal cervical-occlusal face (CV-B) and mesio-distal (MD-V). The data were tabulated and analyzed using the statistical tests of Kolmogorov-Smirnov, ANOVA one-way and Tukey tests (p <0.05). There were no statistically significant differences in the linear values of plaster models between chemical (Glutaraldehyde 2%, sodium hypochlorite 1%) and physical (UV-C radiation) disinfection methods with the control (p> 0.05), the autoclave showed a significant difference in relation to the control and the different methods of disinfection (p <0.05) with greater dimensional change for both impression materials. It can be concluded that the methods of chemical disinfection (Glutaraldehyde 2%, Sodium hypochlorite 1%) and physical (UV-C radiation) maintained the dimensional stability of the dental impression materials alginate and elastomer (condensation silicone).Item A suplementação de vitamina C inibe hiperativação de células de Leucemia Mielóide Crônica induzidas por Lipopolysaccarídeo: envolvimento da sinalização purinérgica(Universidade Brasil, 2021) Pires, Daniela Alves; Vieira, Rodolfo de PaulaChronic myeloid leukemia (CML) is a myeloproliferative neoplasm, characterized by overproduction of white blood cells, with the patients presenting anemia, fatigue, infections, bleeding, and other problems. Thus, an important goal for CML patients is to prevent infections and inhibit the exacerbation of inflammatory processes. In this context, the present study investigated whether vitamin C could inhibit hyperinflammatory activation of K562 cells induced by LPS and whether purinergic signaling is involved in such response. Two doses of vitamin C were used (5 µg/mL and 10 µg/mL) for 2 hours prior LPS (10ng/mL) for 22 hours in K-562 cells (3x105 cells/mL/well). The results demonstrated that both doses of vitamin C significantly reduced LPS-induced the release of IL-6 (5 µg/mL, p<0.01 and 10µg/mL p<0.01) and TNF-alpha (5 µg/mL, p<0.01 and 10µg/mL p<0.01). In contrast, both doses of vitamin C induced the release of the anti-inflammatory cytokine IL-10 (5 µg/mL, p<0.01 and 10µg/mL p<0.01). In addition, 10µg/mL of vitamin C induced the release of klotho(10µg/mL p<0.01), an anti-aging and antiinflammatory protein. Importantly, vitamin C (5 µg/mL, p<0.01 and 10µg/mL p<0.01) reduced ATP release and accumulation in the extracellular milieu as well as reduce the expression at mRNA levels of P2X7 receptor, suggesting a possible mechanism of action. Therefore, we conclude that vitamin C inhibits hyperinflammatory state induced by LPS in K-562 cells involving purinergic signaling.Item Desenvolvimento e avaliação de aplicativo de dispositivo móvel para auxílio no dimensionamento do quadro de profissionais de enfermagem(Universidade Brasil, 2021) Monezi, Marcus Vinícius Belão; Magalhães, Daniel Souza FerreiraThe Fugulin and Braden scales are instruments used in nursing to classify the clinical status of patients in different sectors of a hospital. These instruments allow the elaboration of a System of Classification of Patients (SCP) and to know exactly the scenario of the work environment, to quantify the professionals needed for the assistance. These classification systems subsidize the dimensioning of nursing professionals, who must follow normative criteria of the Federal Nursing Council (COFEN). The objective of the present study is to develop and test an application and its management platform (WEB platform) for the application of these combined scales on a mobile device. This application classifies the patient into different levels of nursing dependency and presents the grouped data of the total number of patients in each sector. The application was designed to be used in a simple way, and was built from the Kotlin programming language, the tool proved to be efficient in the tests performed. Which allows to affirm that this technological resource is efficient for the use that was developed, to replace the old model in printed paper with the use of this program in a mobile device. The work contributed to fill a knowledge gap in the application platforms and in the research in the area. And it is an advance because it allows the assessment and classification of the patient to be made using two scales simultaneously.Item Ensaio clínico cego e randomizado para avaliação de dois protocolos de fotobiomodulação para a prevenção das complicações orais em pacientes transplantados de medula óssea(Universidade Brasil, 2021) Marski, Roberta Silveira da Silva; Nuñez, Silvia CristinaBone marrow transplantation (BMT) or hematopoietic cell transplantation requires high doses of chemotherapy in patients who will undergo HSCT (Hematopoietic Stem Cell Transplantation), this chemotherapy regimen causes the destruction of cells with a high mitotic index leading to damage to the oral and gastric mucosa called Mucositis. The aim of this study was to investigate the efficacy of Photobiomodulation (PBM) in the prevention of oral complications in hematopoietic transplant patients applying PBM daily and comparing it to the application every other day, totalizing 4 weekly applications from the beginning of conditioning to neutrophilic engraftment (bone marrow engraftment) in gender-independent, halogen and/or haploidentical transplant recipients. The volunteers were randomly divided into 2 groups: Daily Laser Group (DLG) P=13; LG4 (4x a week) P=17. All groups were evaluated daily by a trained nursing staff., from the beginning of conditioning D-7 to D+21, the results were cataloged and analyzed in a blind, longitudinal study, according to the WHO scale for evaluation of oral mucositis and pain degree (VAS scale). The groups were submitted to low power laser treatment (Therapy XT-DMC, São Carlos, Brazil) with a wavelength of 660nm, Power of 100mW, exposure time of 20 s delivering 2J per point throughout the oral cavity. Data related to xerostomia, odynophagia and degree of mucositis were analyzed over 21 days and the data were compared statistically using the Mann-Whitney test. The statistical comparison results for xerostomia (D+8 p=0.4434), odynophagia (D+8 p=0.8560) and mucositis (D+8 p=0.7285) showed no significant differences at any time during the study. According to the results, the PBM protocol on alternate days is as efficient as the daily application for the prevention of oral complications in patients who underwent HSCT.Item Avaliação comparativa entre as técnicas All-on-four e Four-onpillars em planejamentos virtuais 3D associadas a cirurgias guiadas em maxilas atróficas(Universidade Brasil, 2021) Maia, Marcelo do Lago Pimentel; Magalhães, Daniel Souza FerreiraThorough technical knowledge and anatomical understanding are critical for optimal surgical results. The difficulty of complete maxillary surgery can vary significantly depending on the complexity of the anatomy or bone defect. Guided surgery is currently a relevant option for bringing to the patient fewer surgical complications and is directly related to 3D virtual planning for the success of the case. In this work, we analyze and compare two methods of planning guided in software for the manipulation of dental implants, associated with the All-on-four (A.F.) and Four-on-pillars (F.P.) techniques used in patients with atrophic maxillae. Forty-two images of totally edentulous patients were analyzed, 30 of which were planned using ImplantViewer software for volume assessment and ImageJ software for area assessment. The volumes were acquired in a CRANEX 3D volumetric tomograph model from the Soredex brand. In each planning, the height and width of the bone remnant was used as guidance and the implants were installed virtually. The average area of the Fouron-pillars technique was 4.9x (p<0.0001) greater than the average area with the Allon-four technique, this represents a difference of 489%, which in the same force applied by the jaw we have a 4.9x lower pressure, that is, a better distribution of forces on the jaws. It was not possible to notice a statistical difference between the success proportions (p=0.2542), showing that the techniques have a non-different (similar) success proportion. We conclude that the area formed in the Four-on-pillars surgical planning is larger than in the All-on-four planning and also that there is no technique with successful advantages over another, therefore the Four-on-pillars technique becomes an excellent option as a treatment for atrophic jaws.