Engenharia Biomédica
URI permanente para esta coleçãohttps://repositorioacademico.universidadebrasil.edu.br/handle/123456789/33
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Item Efeitos agudos da fotobiomodulação sobre variáveis respiratórias e a capacidade funcional em tabagistas e ex-tabagistas: ensaio clínico randomizado, triplo-cego e placebo controlado(Universidade Brasil, 2020) Macedo, Thaline; Ferraresi, CleberIntroduction: Smoking, in addition to affecting the functionality of the respiratory muscles, can increase resistance to airflow and reduce the individual's functional capacity, impairing their quality of life. Photobiomodulation (FBM) has gained prominence for being an effective resource in promoting the improvement of muscle performance in athletes and in the face of some diseases. However, studies on the acute effects of FBM on respiratory variables and functional capacity in smokers and ex-smokers are scarce in the literature. Objectives: To evaluate the acute effects of FBM applied to respiratory muscles, on lung function and respiratory muscle strength. Material and methods: A randomized, crossover, triple blind and placebo-controlled clinical trial was conducted. 16 volunteers participated in the study, 10 smokers and 06 ex-smokers. All volunteers were randomly subjected to two intervention sessions: 1) an effective FBM session applied to the region of the main respiratory muscles through a cluster of 69 LEDs (light-emitting diodes) with a total power of 690 mW and energy total of 62 Joules, containing 35 LEDs in the red range (630 ± 10 nm; 10 mW; 0.2 cm2; 31.5 J) and 34 LEDs in the infrared range (830 ± 20 nm; 10 mW; 0.2 cm2; 30.6 J); irradiation time in each treatment region was 90 seconds. 2) a placebo FBM session, in which the same procedures as the effective session were followed, but the equipment did not emit light. All volunteers were assessed at 3 times: 1) pre intervention, 2) 1 hour after the intervention and 3) 24 hours after the intervention. A one-week washout was performed between the FBM and placebo sessions. All volunteers underwent pulmonary function assessment using spirometry, thoracoabdominal mobility using axillary, xiphoid and abdominal levels. In the post intervention moments, functional capacity was also assessed using the 6-minute walk test. For data analysis, a 5% significance level was adopted. Results: There were no significant differences for any of the variables of spirometric outcome, cirtometry and 6MWT minutes (p> 0.05) in the comparison between groups. Conclusion: the main results of this study showed that a single FBM session with the parameters used, applied to the respiratory muscles was not effective in improving lung function, respiratory muscle strength, thoracoabdominal mobility and functional capacity in smokers and ex-smokers.Item Efeitos agudos da terapia de fotobiomodulação sobre a glicemia e a concentração de glicogênio muscular de ratos(Universidade Brasil, 2020) Castro, Kenia Mendes Rodrigues; Ferraresi, Cleber; Soto, Carlos Alberto TellezPhotobiomodulation (PBM) has many effects on the energetic metabolism of musculoskeletal tissue, such as increased glycogen synthesis. However, these effects can systemic, such as glycemic control. The primary objective was to evaluate the effects of photobiomodulation (PBM) by LEDs (light-emitting diodes) on glycemic levels and muscle glycogen concentration in non-diabetic rats. The secondary objectives were to evaluate the acute effects of 4 doses of PBM (dose-response: sham, 10 J/cm2, 30 J/cm2, 60 J/cm2) on glycemic levels in rats over 6 hours (time-response: pre irradiation,1 hour, 3 hours, 6 hours) after irradiation; and to evaluate the acute effects of dose-response of PBM on muscle glycogen levels in rats after 24 hours of irradiation.Finally, to correlate glycemic modulations with muscle glycogen concentrations after applying 4 different doses of PBM. Twenty-four Wistar rats were randomly and equally allocated to four groups: sham (placebo therapy), PBM 10J/cm2, PBM 30J/cm2, and FBM 60 J/cm2. The animals fasted for 6 hours. Feeding was interrupted immediately before PBM. Evaluations of glucose level were performed at pre-irradiation times (immediately before PBM), 1h, 3h and 6h. Muscle glycogen synthesis was measured 24 hours after PBM. PBM used an arrangement of 69 LEDs (light-emitting diodes) with 35 reds (630 ± 10 nm) and 34 infrared (850 ± 20 nm); 114 mW/cm2 for 90 s (10J/cm2), 270s (30J/cm2), 540s (60J/cm2) applied to the back, gluteus, and hind limbs of the animals. The 10J/cm2 group showed lower glycemic variability over 6 hours (5.92 mg/dL) compared to the sham (13.03 mg/dL), 30J/cm2 (7.77 mg/dL) and PBM 60 J/cm2 (9.07 mg/dL) groups. The PBM groups had the highest increase in muscle glycogen (10 J/cm2 > 60 J/cm2 > 30 J/cm2 > sham), characterizing a three-phase dose-response to PBM. There was a strong negative correlation between glycemic variability over 6h and muscle glycogen concentration for 10J/cm2 (r= -0.94; p<0.001) followed by 30 J/cm2 (r= -0.84; p<0.001) and 60J/cm2 (r= -0.73; p<0.006). The results suggest that PBM can play a very important role in the control of glycemic levels, and its possible mechanism of action is the induction of greater muscle glycogen synthesis independent of physical exercise.