Engenharia Biomédica

URI permanente para esta coleçãohttps://repositorioacademico.universidadebrasil.edu.br/handle/123456789/33

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Comparação dos efeitos da fotobiomodulação a laser nos comprimentos de onda de 660 nm e 808 nm em queimaduras de espessura total em ratos: estudo pré clínico.
(Universidade Brasil, 2024) Kuamoto, Juliana Narcizo; Andrade, Ana Laura Martins de
Burns are defined as thermal injuries that affect organic tissues, and can be classified in degree, according to their severity, with grade 3 burns being the most serious form of the injury. Concern regarding the rehabilitation of burn patients is related to recovery time and the severity of the injury's sequelae. Photobiomodulation therapy (TFBM) has gained prominence in the treatment of skin lesions, but the selection and application of parameters is still controversial. This study aims to evaluate the effects of TFBM using Red (660 nm) and Infrared (808 nm) laser on the quality of tissue regeneration in 3rd Degree burns in rats. Thirty male Wistar rats were used, randomly divided into 3 groups (n=10): control groups (C), with laser applied turned off, red laser group (GLV), treated only with TFBM using the 660 nm red laser and, infrared laser group (GLI), treated with 808 nm infrared laser. The animals were treated three times a week, for 21 days, totaling nine applications, using parameters suggested in the literature (ANDRADE, 2016). Photographic documentation was carried out on the first and last day of treatment to analyze wound contraction. On the 21st day, after the last treatment, the animals were euthanized, and tissue samples were collected for histological analyses.After the analyses, it was observed that the GIV, when compared to the GC and GV, showed an advanced phase of recovery and revascularization, with a thinner epidermis, minimal inflammatory infiltrate, and a well-established collagen organization throughout almost the entire dermis.
Efeitos da terapia ILIB modificada em pacientes com sepse internados no ambiente hospitalar
(ILIB, 2024) Sousa, Adriano Correia de; Andrade, Ana Laura Martins de
Introduction: sepsis is a systemic inflammatory response syndrome (SIRS) triggered by a suspected or confirmed infection, which can progress to severe sepsis when associated with organ dysfunction or septic shock. This condition is one of the main challenges for healthcare organizations, being one of the main causes of death in hospitalized patients. Objective: to evaluate the effects of modified ILIB therapy in patients with sepsis admitted to a hospital setting. Methodology: Thirty septic patients participated in the study and were randomly divided into two groups: control group (CG, n = 15), in which participants received the ILIB technique (modified) with the laser turned off, and treated group (GILIB, n = 15), which received the ILIB technique with the laser turned on, both for 30 minutes daily for five consecutive days. Conventional treatments were maintained in both groups. Clinical parameters, such as leukocytes, PaCO2, PaO2, lactate, creatinine, SpO2, pH and HCO3, were monitored daily. Results: modified ILIB therapy provided significant improvements in the clinical parameters of patients treated in the ILIB group, leukocytes (p<0.001), ph (p<0.001), PaO2 (p<0.05), PaCO2 presented an average within normal levels, HCO3 there were no significant differences, lactate on the 4th and 5th (p<0.05), SpO2 on the 2nd day (p<0.001), 3rd (p<0.0001), 4th (p<0.05), 5th (p<0.0001) and Creatinine on the 1st day of intervention (p<0.0001), 2nd (p<0.05), 3rd (p<0.05), 4th (p<0.05) and 5th (p<0.05). Conclusion: These improvements suggest that the modified ILIB may be a promising therapeutic option in the management of sepsis, contributing to patient recovery.