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Resultados da Pesquisa
Item Efeitos agudos da fotobiomodulação sobre variáveis respiratórias e a capacidade funcional em tabagistas e ex-tabagistas: ensaio clínico randomizado, triplo-cego e placebo controlado(Universidade Brasil, 2020) Macedo, Thaline; Ferraresi, CleberIntroduction: Smoking, in addition to affecting the functionality of the respiratory muscles, can increase resistance to airflow and reduce the individual's functional capacity, impairing their quality of life. Photobiomodulation (FBM) has gained prominence for being an effective resource in promoting the improvement of muscle performance in athletes and in the face of some diseases. However, studies on the acute effects of FBM on respiratory variables and functional capacity in smokers and ex-smokers are scarce in the literature. Objectives: To evaluate the acute effects of FBM applied to respiratory muscles, on lung function and respiratory muscle strength. Material and methods: A randomized, crossover, triple blind and placebo-controlled clinical trial was conducted. 16 volunteers participated in the study, 10 smokers and 06 ex-smokers. All volunteers were randomly subjected to two intervention sessions: 1) an effective FBM session applied to the region of the main respiratory muscles through a cluster of 69 LEDs (light-emitting diodes) with a total power of 690 mW and energy total of 62 Joules, containing 35 LEDs in the red range (630 ± 10 nm; 10 mW; 0.2 cm2; 31.5 J) and 34 LEDs in the infrared range (830 ± 20 nm; 10 mW; 0.2 cm2; 30.6 J); irradiation time in each treatment region was 90 seconds. 2) a placebo FBM session, in which the same procedures as the effective session were followed, but the equipment did not emit light. All volunteers were assessed at 3 times: 1) pre intervention, 2) 1 hour after the intervention and 3) 24 hours after the intervention. A one-week washout was performed between the FBM and placebo sessions. All volunteers underwent pulmonary function assessment using spirometry, thoracoabdominal mobility using axillary, xiphoid and abdominal levels. In the post intervention moments, functional capacity was also assessed using the 6-minute walk test. For data analysis, a 5% significance level was adopted. Results: There were no significant differences for any of the variables of spirometric outcome, cirtometry and 6MWT minutes (p> 0.05) in the comparison between groups. Conclusion: the main results of this study showed that a single FBM session with the parameters used, applied to the respiratory muscles was not effective in improving lung function, respiratory muscle strength, thoracoabdominal mobility and functional capacity in smokers and ex-smokers.Item Desenvolvimento de uma manta de LEDs em formato de fita ajustável para aplicações de terapia de fotobiomodulação(Universidade Brasil, 2020) Silva Filho, Francisco do Nascimento; Costa, Mardoqueu Martins da; Ferraresi, CléberLight emitting diodes (LEDs) are photobiomodulatory devices formed by solid semiconductors joined together and that generate a reliable and high power light source in narrow ranges of light bands (between 20-50 nm) and that have been gaining prominence in the context of health and aesthetics. In this context, the objective of the work was to develop an LED strip in an adjustable ribbon format for photobiomodulation applications and an application (App) for mobile device and equipment control via Bluetooth. The device was formed by an irradiation blanket, electronic control equipment using the Arduino platform and the control app with an MIT App Inventor for Android software interface (Massachusetts Institute of Technology). Based on what was found in this study, it appears that the development of an LED mat for this purpose proved to be feasible. It was also observed that the features of the App were compatible with the platform in question. Thus, the present research found that the LED blanket developed with photobiomodulation proved to be viable, and future work is essential, adding new features and functions, optimizing its usability to professionals working in the aesthetic and physical education fields.Item Avaliação do conhecimento sobre fotobiomodulação dos fisioterapeutas no Brasil(Universidade Brasil, 2021) Arruda Neto, Euler; Nunez, Silvia CristinaPhysiotherapy is the profession that assesses, rehabilitates, prevents, recovers, as well as restores, develops, and conserves the individual's capacity through physical resources such as ultrasound, heat and light. Electrophysical resources are described and recommended in undergraduate courses and among these we find the use of low power lasers. Brazil is one of the countries with the most publications in the world in the area known as Photobiomodulation (PBM), however, it is not clear the access that physiotherapy clinicians have to the advances obtained in scientific research. The purpose of this study is to verify, through an electronic form, the knowledge of physical therapists enrolled in class councils about PBM in daily practice. An electronic questionnaire Google Form was developed, and it was sent by email, WhatsApp social networks, SMS, and printed forms were also distributed. The distribution started in the region of Goiás and the Federal District with the support of CREFITO 11 and then expanded to other regions. In total 106 physiotherapists answered the questionnaire. Of these 50% used lasers in the clinic, while 10.4% had never used lasers. After obtaining the data and according to the responses obtained, we observed 50% that physiotherapy professionals. 81.4% said they did not use it because they did not have the equipment and 10.2% indicated the cost as a reason for not using it. Among the participants, 62.3% said they had not made any updates in the area in the last 3 years and of those who said they had updated the courses up to 1 hour in duration were the majority. 76.5% also never calibrated their equipment and 45.7% said they used the protocols they learned at graduation. Based on the results, we conclude that there is a need for greater dissemination of the scientific knowledge obtained in the field of PBM in physical therapy so that the advances are effectively passed on to professionals who work clinically in the area.Item Fotobiomodulação no manejo da mucosite oral em hospitais do Brasil: a busca por uma diretriz clínica(Universidade Brasil, 2022) Passos, Januaria Lima Ribeiro; Nunez, Silvia CristinaCancer is one of the most frequent diseases worldwide. Oral mucositis (OM) is a common and debilitating complication of chemotherapy (CT), head and neck radiotherapy (RT) and hematopoietic stem cell transplantation (HSCT). Photobiomodulation (PBM) IS one of the therapeutic alternatives for prevention and treatment of OM. The objective of this study was to carry out a survey of data from the protocols applied for PBM in public and private hospitals in Brazil. A cross-sectional, quantitative study was carried out with the application of questionnaires to dentists, built specifically to understand the establishment of protocols and their outcomes, to verify if there is a consensus on the use of PBM in OM in Brazil. According to the analysis of the results, we observed that dentists work both in public and private hospitals in Brazil and most of them are employed by the institution. The PBM protocols, as well as, the initial assessment of patients, are performed by the dental surgeon who claims to use protocols based on scientific evidence. More modern equipment’s with 100 mW of power are the most used ones and, according to the interviewees, frequently checked. For OM induced by QT and HSCT, preventive and therapeutic protocols were cited, while for RT only one protocol was cited. The prevailing wavelength was red, and only for therapeutic HSCT the 2 wavelengths had the same frequencies. In all cases, energies of 1 and 2 J were the prevailing ones, with irradiation performed in a punctual way. The frequency of irradiation depends on the duration of RT, or it is performed for 5 days in a week for QT and HSCT, and only in therapeutic HSCT did the interviewees point out the symptomatology and the clinical aspect as relevant for the choice of treatment. According to our results, the treatment of OM with PBM presents constancy of energy and form of application, which may explain its spread and successful application in different regions of the country in a homogeneous way.Item Uso da terapia por fotobiomodulação a laser no tratamento do paciente com covid-19 em unidade de terapia intensiva(Universidade Brasil, 2022) Neves Neto, Messias Augusto das; Tim, Carla Roberta; Garcia, Lívia AssisThe pandemic context ended up causing the exploration of new treatment methods in the face of the conditions presented by patients in this period. In this bias, photobiomodulation therapy has been characterized as a viable therapeutic aspect for the treatment of patients with COVID-19 in the Intensive Care Unit, since it has great potential for biological alteration. To demonstrate the feasibility of the treatment, a case report was carried out that aimed to evaluate the effects of photobiomodulation as an adjuvant treatment in a patient with COVID-19 admitted to an intensive care unit (ICU). A 68-year-old man with severe COVID-19 received 5 sessions of PBMT by laser, once daily. The treatment protocol consisted of the association of the application of local PBMT with 808 nm laser and the application of a transdermal laser in the radial artery with a 660 nm laser. The patient was evaluated before and after treatment through radiological evaluation, blood tests and oxygen requirement. Oxygen saturation (SpO2) increased from 92% in the support of oxygen with a mask without rebreathing 13 L/min to 95% in the delivery of O2 2 L/min in a nasal catheter, tolerating the withdrawal of oxygen therapy for 20 minutes. This case report showed that the use of photobiomodulation therapy in the adjuvant treatment of a patient with COVID-19 decreases oxygen needs over several days and without the need for a ventilator. Future controlled clinical trials are needed to assess the effects of PBMT on clinical outcomes in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).Item Ensaio clínico cego e randomizado para avaliação de dois protocolos de Fotobiomodulação para a prevenção das complicações orais em pacientes transplantados de medula óssea(Universidade Brasil, 2021) Marski, Roberta Silveira da Silva; Nunez, Silvia CristinaBone marrow transplantation (BMT) or hematopoietic cell transplantation requires high doses of chemotherapy in patients who will undergo HSCT (Hematopoietic Stem Cell Transplantation), this chemotherapy regimen causes the destruction of cells with a high mitotic index leading to damage to the oral and gastric mucosa called Mucositis. The aim of this study was to investigate the efficacy of Photobiomodulation (PBM) in the prevention of oral complications in hematopoietic transplant patients applying PBM daily and comparing it to the application every other day, totalizing 4 weekly applications from the beginning of conditioning to neutrophilic engraftment (bone marrow engraftment) in gender-independent, halogen and/or haploidentical transplant recipients. The volunteers were randomly divided into 2 groups: Daily Laser Group (DLG) P=13; LG4 (4x a week) P=17. All groups were evaluated daily by a trained nursing staff., from the beginning of conditioning D-7 to D+21, the results were cataloged and analyzed in a blind, longitudinal study, according to the WHO scale for evaluation of oral mucositis and pain degree (VAS scale). The groups were submitted to low power laser treatment (Therapy XT-DMC, São Carlos, Brazil) with a wavelength of 660nm, Power of 100mW, exposure time of 20 s delivering 2J per point throughout the oral cavity. Data related to xerostomia, odynophagia and degree of mucositis were analyzed over 21 days and the data were compared statistically using the Mann-Whitney test. The statistical comparison results for xerostomia (D+8 p=0.4434), odynophagia (D+8 p=0.8560) and mucositis (D+8 p=0.7285) showed no significant differences at any time during the study. According to the results, the PBM protocol on alternate days is as efficient as the daily application for the prevention of oral complications in patients who underwent HSCT.Item Avaliação da fototerapia com diferentes comprimentos de onda no tratamento da Alopécia androgenética(Universidade Brasil, 2024) SILVA, Leandro Ferreira da; BAPTISTA, AlessandraAndrogenetic alopecia (AGA) is a hair dysfunction that promotes the transformation of terminal hairs into vellus hairs and consequent baldness. Phototherapy (FT) uses light, usually laser or LED, to stimulate, heal and/or regenerate damaged tissues and has been identified as a safe and promising resource for the treatment of AGA. The purpose of this study is to compare different wavelengths in the treatment of AGA. 10 volunteers were selected, randomly divided into 2 groups: Red Light Group (GLV, n=5) and Blue Light Group (GLA, n=5). The groups received point irradiation (4J/point), respectively, with the Venus equipment (MMOptics, São Carlos, Brazil), GLV (l= 660nm, P= 100 mW, for 40 s) and GLA (l= 440 nm, P = 150 mW, for 26.6 s). The interventions were carried out once a week, for 90 days, totaling 12 treatment sessions. The emergence of new hairs was analyzed by comparing the photographic record before any intervention (T1) and at the end of treatment (T2). The relationship between vellus threads and terminal threads was analyzed by trichoscopy with polarized light, before and at the end of treatment. A specific quality of life assessment questionnaire for androgenetic alopecia (Women's Androgenetic Alopecia Quality of Life Questionnaire -WAA-QoL) before and after the end of the interventions. The results showed that both red light and blue light, in the parameters tested in this study, led to an increase in the number of terminal strands after treatment (p< 0.05), which allowed a reduction in the central parting of the treated hair. The evaluation of the WAA-QoL questionnaire showed a lower percentage of responses with a higher degree of dissatisfaction after both treatments. Therefore, we can conclude that the use of phototherapy is an effective therapeutic resource in the treatment of AGA with red or blue light, in the parameters tested in this study.Item Estudo clínico randomizado controlado do efeito da fotobiomodulação vascular na hipertensão arterial(Universidade Brasil, 2023) Silva e Lima, Veridiana Palmiro da Silva; Parizotto, Nivaldo AntonioSystemic arterial hypertension (SAH) constitutes a serious public health problem due to its magnitude, risk, and difficulties in control, and is associated with a high rate of morbidity and mortality due to its promotion of cardiovascular diseases (CVDs). It is suggested that endothelial dysfunction associated with SAH is related to local and systemic inflammation. Inflammation is known to be a protective physiological response to harmful and/or pathogenic stimuli, and endothelial dysfunction is a pro-inflammatory state with altered endothelial functions, which is associated with SAH, a multifaceted disease. This study evaluates the effect of this technique in humans, as large animal studies have yielded positive results in reducing heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP). The objective was to analyze the effect of laser photobiomodulation on the radial artery on hemodynamic variables in uncontrolled hypertensive patients. It was a double-blind, randomized, placebo-controlled clinical trial with a longitudinal design and a quantitative approach, conducted in a public hospital. Volunteers were randomly allocated between Group A (laser intervention) and Group B (placebo control), of both sexes, aged between 29 and 83 years, with uncontrolled SAH and difficulties in controlling blood pressure. Participants underwent weekly sessions of low-intensity laser photobiomodulation in the radial artery region, using red light (660 nm) and radiant energy of 180 J per session, lasting 30 minutes, over a period of six weeks, totaling six sessions (1/week). The results showed a reduction in arterial hypertension when active photobiomodulation was performed compared to the placebo group, with a decrease of approximately 12,22% in SBP and 5,43% in DBP, while in the placebo group, there was an approximate reduction of 5,13% in SBP and 3,18% in DBP. It is hoped that photobiomodulation may be used as a new alternative for the treatment of systemic arterial hypertension.Item A relação entre a irradiação transcutânea do sangue – ILIB modificada e os níveis de cortisol salivar em cuidadores de idosos saudáveis(Universidade Brasil, 2021) Trindade, Monaiza Moura; Baptista, AlessandraFormal caregivers usually have exhaustive work scale that can trigger emotional changes and a decrease in the quality of life of these professionals. The use of ILIB (Intravascular Laser Irradiation of Blood) can improve the immunological activity of the blood, in addition to facilitating blood circulation and has been used in the treatment of different diseases. The aim of this study was to verify the effects of ILIB, applied transcutaneous, in relation to the levels of salivary cortisol of caregivers of formal elderly in long-term care institutions, who work during the day and night. Forty-two caregivers of formal elderly people were divided into 6 groups: Day Group (DG) (n=7); Day ILIB Group (DILIBG) (n=7); Day ILIB/placebo group (DPG) (n=7); Night Group (NG) (n=7); ILIB Night Group (NILIBG) (n=7); and Night ILIB/placebo Group (NPG) (n=7). Volunteers in the ILIB and ILIB / placebo groups received ILIB, in the radial artery region, by means of a low-power laser (Laser Duo, MMOPTICS, São Carlos, Brazil), l= 660 nm, P = 100 mW / 30 min, every other day, for 2 weeks, totaling 8 sessions of treatment/placebo, while the groups: GD and GN performed salivary collection on the day off and on the workday. All participants answered the quality of life questionnaire (QLQ) before any procedure and saliva collections for volunteers in the ILIB and ILIB/placebo groups were performed before any procedure; 24 h and 48 h after 8 treatment/placebo sessions, while the groups: DN and NG performed salivary collection on the day off and on the workday. The QLQ results did not show statistically significant differences between daytime and nighttime workers (p>0.05). Regarding cortisol quantification, the results showed statistically significant decreases (p<0.05) in salivary cortisol levels, both in the ILIB groups and in the placebo groups. Therefore, we can conclude that it was possible to measure the salivary cortisol levels of caregivers of formal elderly in long-stay institutions, who work day and night, treated or not with ILIB. However, ILIB cannot help to reduce salivary cortisol levels in caregivers of elderly people in long-term care facilities.Item Comparação dos efeitos da fotobiomodulação a laser nos comprimentos de onda de 660 nm e 808 nm em queimaduras de espessura total em ratos: estudo pré clínico.(Universidade Brasil, 2024) Kuamoto, Juliana Narcizo; Andrade, Ana Laura Martins deBurns are defined as thermal injuries that affect organic tissues, and can be classified in degree, according to their severity, with grade 3 burns being the most serious form of the injury. Concern regarding the rehabilitation of burn patients is related to recovery time and the severity of the injury's sequelae. Photobiomodulation therapy (TFBM) has gained prominence in the treatment of skin lesions, but the selection and application of parameters is still controversial. This study aims to evaluate the effects of TFBM using Red (660 nm) and Infrared (808 nm) laser on the quality of tissue regeneration in 3rd Degree burns in rats. Thirty male Wistar rats were used, randomly divided into 3 groups (n=10): control groups (C), with laser applied turned off, red laser group (GLV), treated only with TFBM using the 660 nm red laser and, infrared laser group (GLI), treated with 808 nm infrared laser. The animals were treated three times a week, for 21 days, totaling nine applications, using parameters suggested in the literature (ANDRADE, 2016). Photographic documentation was carried out on the first and last day of treatment to analyze wound contraction. On the 21st day, after the last treatment, the animals were euthanized, and tissue samples were collected for histological analyses.After the analyses, it was observed that the GIV, when compared to the GC and GV, showed an advanced phase of recovery and revascularization, with a thinner epidermis, minimal inflammatory infiltrate, and a well-established collagen organization throughout almost the entire dermis.