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Item Desenvolvimento de aplicativo para dispositivos móveis de mensuração de injestão proteica diária por pessoas idosas(Universidade Brasil, 2022-09-30) Duarte e Silva, Fábio Carniello; Simonato, Luciana Estevam; Magalhães, Daniel Souza FerreiraTechnology is part of the daily life, and the ageing population will expand its use by the elderly people for several purposes, health care for example. Nutrition in geriatrics is gaining increasing relevance, in particular, the goals of protein ingestion, that have been increasing recently. Therefore, mobile apps can be used to track inadequacies in this regard. This research aimed to develop an app that performs a 24-hour food diary by the elderly user, in an automated way, submitting it to quality tests and usabilityvalidation. It was developed with a focus on the specificities of this group and subjectedto quality tests in an exhausting way. The usability was evaluated in two stages: Stage1(N=8) -central group discussion, which took place before the elaboration of its finalversion, including elderly users in the development process; and Stage 2 (N = 18) -evaluation by elderly participants who did not have cognitive decline identified by the10-point cognitive screening tool (10-CS), using the System Usability Scale (SUS scale). The final version of the PROT+ app for Android, obtained after quality tests andproposals made by the focused discussion group, presented screens for simple andintuitive use, and a tutorial video to guide the user. Data from the SUS scale performedby 16 participants, were analyzed by groups divided by schooling and age range. The average of the groups with schooling from zero to four years, five to 11 years, andhigher than or equal to 12 formal years of study were 80 (Interquartile Range (IQR) 48.13), 95 (IQR 15) and 92.5 (IQR 10), respectively. And for age range from 60 to 69 years old, 70 to 79 years old, and over 80 years old, were 95 (IQR 8.75), 85 (IQR33.75), and 87.5 (IQR 10), respectively. There were no differences in usability betweenthe groups by schooling, but there was a large difference between the 60-69 and 70-79 age groups. However, all averages were higher than the scores of other applicationsdeveloped for elderly users and satisfactory by the SUS scale. Therefore, the PROT+app is a geriatric nutritional tool, which is easy to use, with an interface adapted to the specificity of its target audience and demonstrated satisfactory performance in allrequirements evaluated after functional and non-functional quality tests, as well as usability.Item Estudo sobre a epidemiologia dos acidentes com escorpiões no Estado de São Paulo - SP(Universidade Brasil, 2022-08-17) Almeida, Estelita Aparecida de Souza; Cogo, José Carlos; Magalhães, Daniel Souza FerreiraScorpionism is considered a public health problem in developing countries. In Brazil, scorpions are responsible for the highest number of accidents with venomous animals,exceeding the number of accidents with spiders and snakes. The present work aimedo study the epidemiology of the accident with scorpions in the municipality of Fernandópolis,comparing with those that occurred in the macro-region of the Regional Intermanagers Commission (CIR) and in the State of São Paulo. The study wasetrospective and the information was collected from existing information in the DATASUS database, which is a database open to the public (Department ofnformatics of the Unified Health System in Brazil) and SINAN (Information System forDiseases notification form. The period analyzed was from 2013 to 2017. Variablesrelated to the accident were analyzed: cases that occurred in the State of São Paulo, in the CIR region and in the municipality of Fernandópolis;victim-related variables:sex, race; age group, variables related to poisoning and treatment: time elapsedbetween the accident and care in the emergency room, classification of the case (mild,moderate and severe) and evolution of the case. This work also proposed to create afolder with information about scorpionism to be disseminated to the general population. Our results show that in this period there was a significant increase in accidents, withthe growth in the CIR region and the municipality of Fernandópolis greater than thegrowth in the state. Men were the most affected by scorpionism, and the age groupthat suffered the most from this type of accident was between 20 and 59 years old,with the white race being the most affected. Most accidents were classified as mild, State of São Paulo, and emergenrcy room that suffered the most from this type of accident was between 20 and 59 years old,with the white race being the most affected. Most accidents were classified as mild,with deaths only in the data relating to the State of São Paulo, and emergency roomcare occurred within the first hour after the accident. We conclude that the accidentwith scorpions is increasing in the studied regions and that there is an urgent need totake containment measures such as prioritizing the preservation of the environment, avoiding accumulation of garbage and debris and creating means of dissemination tothe population on how to avoid this type of accident. The results of this work and thefolder created containing information about scorpionism fill a gap in the scientific fieldof popular knowledge about the accident with scorpions and the first aid that should betaken in the case of an accident with scorpions. It is also a document to guide futurepublic policy proposals to combat scorpionism in the region.Item Avaliação dos efeitos da ILIB modificada transdérmica na reabilitação cardiopulmonar na síndrome Pós-COVID-19(Universidade Brasil, 2022-08-19) Chaves, Camila Teixeira de Oliveira Penna; Frade-Barros, Amanda FaragePost-COVID syndrome are persistent symptoms such as shortness of breath, fatigue, memory loss, fatigue, muscle weakness, hair loss, and other symptoms. Cardiopulmonary rehabilitation should be started early for these patients. Modified transdermal ILIBm (Intravascular Laser Irradiation of Blood) is a blood and systemic photobiomodulation therapy that may contribute to improvement in general conditions and rehabilitation after infection. The objective of this study was to evaluate the efficacyof the use of transdermal ILIBm in the radial artery associated with cardiopulmonar rehabilitation in post-COVID-19 patients. This is a randomized controlled clinical trialwith 12 volunteers of both sexes. We divided into 2 randomized groups, ILIBm groupwith 30 minutes irradiation and the cardiopulmonary rehabilitation and compared withthe control group ILIBm off and the cardiopulmonary rehabilitation, evaluated beforeand after the program. The interventions were performed 2x per week for 4 weeks. Peak expiratory flow, Walk Test (6 min), Dynamometry, Muscle Strength (MRC), Quality of life (SARC-VIDA software, which is based on the SF-36 questionnaire), andbiochemical and hematological tests were evaluated. The rehabilitation program consisted of aerobic exercises, resistance training, and respiratory training. The resultsobtained in the intergroup analysis showed non-significant statistics, in the intragroupanalysis significant positive results in the ILIBm group, with improvement in musclestrength by dynamometry, in peak expiratory flow, in the BORG scale during the 6-minute walk test and in quality of life in the vitality and functional capacity parameters.Even with some statistically insignificant results, 100% of the participants reported atthe end improvement of symptoms or even disappearance in both groups. Weconclude that cardiopulmonary rehabilitation is necessary in patients convalescingfrom post-covid-19 syndrome and when associated with ILIBm showed greater resultsin the parameters of muscle strength, peak expiratory flow, 6-minute walk test andquality of life.Item Asma em adultos x crianças : diferenças entre a função pulmonar e a mecânica e os mediadores fibróticos pulmonares(Universidade Brasil, 2022-02-10) Figueiredo, José Eduardo Garbelini; Vieira, Rodolfo de PaulaItem Efeitos da prática regular da atividade física sobre a função pulmonar no contexto do estresse crônico relacionado ao trabalho(Universidade Brasil, 2022-06-24) Scarano, Kleber Torres; Vieira, Rodolfo de PaulaCircadian rhythm changes negatively impact several aspects of health, including lung function. The chronic shift work scale classically induces changes in circadian rhythm. On the other hand, regular physical activity is able to improve and preserve lung function. In this sense, although it has already been shown that military policeofficers working on an alternate shift schedule present alterations in lung function, itis not known how much regular physical activity is able to preserve or prevent thedecline of lung function in this population, what is the purpose of this project. In thiscontext, military police officers(n=25;38.73±6.92 years) who work on a 12 x24hour and 12 x 48 hour non-physically active work scale will be evaluated incomparison with military police officers (n=25;32.92±5.87 years) who work on a 12 x 24-hour work scale and 12 x 48 hours who engage in physical activity. The parameters evaluated will be: lung function and pulmonary mechanics. Statisticalanalysis and graphics will be performed using the Graphpad Prism 5.0 softwares. Theunpaired Student t test will be used for comparison between groups. The value ofp≤0.05 will be considered as statistically different.Item Plano de logística sustentável para empresas de transporte(Universidade Brasil, 2020) Fernandes, Alexandre Chacon; Vanzela, Luiz SérgioDue to the importance for companies to pursue ESG (Environmental, Social and Governance) practices in order to be more responsible in relation to environmental, social and governance issues and improve their reputation in the market, it is imperative to develop methodologies that facilitate achieving these goals. Therefore, the objective of this work was to develop the Company Sustainability Diagnosis System (DISE System) and apply it to assist a transport company in Fernandópolis - SP in the elaboration of their Sustainable Plan for Transport Logistics (SPTL). The methodology used for developing the system of diagnosis and classification of companies was based on the ten principles of the UN Global Compact. The system, which was called the Company Sustainability Diagnosis System or “DISE” System, allows classifying the company's level of sustainability from a scoring system, obtained from surveys about the company. Scores are determined by criteria and calculated by simple equations. After its development, its application was carried out in a transport company based in Fernandópolis - SP, for which it was possible to classify it as "moderate sustainability" and propose an action plan that will compose their Sustainable Plan for Transport Logistics (SPTL), with goals of achieving sustainability in 2026. Based on the results, it was concluded that the DISE System (Company Sustainability Diagnosis System) made it possible to diagnose, in an easy and objective way, a transport company in the municipality of Fernandópolis - SP. As a result, a technical instruction manual for the application of the DISE system was also elaborated for companies in general, assisting them in ESG practices, in improving their reputation in the market and in their pursuit of sustainability.Item Efeitos deletérios da ingestão de microplástico de polipropileno em Tilápias-do-nilo (Oreochromis niloticus)(Universidade Brasil, 2020) Nascimento, Luan de Souza do; Belo, Marco Antonio de Andrade; Kozusny-Andreani, Dora InésThe high molecular weight polymers, widely used in the packaging of several products, generates residues of slow degradation, accumulating in nature and transforming into microparticles during their decomposition process, being called microplastics. Based on the environmental importance represented by the accumulation of polymeric materials in aquatic organisms, the objective of this study was to evaluate the effect of daily ingestion of polypropylene microplastic on the health of tilapia (Oreochromis niloticus). Sixty fish weighing around 200 g were used, coming from the same spawning, placed in six aquariums, with a capacity of 100 L of water each (n=10). The aquariums were supplied with running water devoid of chlorine, from an artesian well, with a flow of 1 L/min, constituting the following treatments: T1: Control (without the addition of polymer), T2 and T3: (fed with ration containing 100 μg and 500 μg of polypropylene/kg of body weight, respectively). After a period of 30 days of feeding, the animals were euthanized for analysis of the blood count, leukogram, serum biochemistry, microbiological analysis of the animals' intestine, histopathological and somatic analysis of the organs. In the serum biochemical study, a significant increase in cholesterol levels and serum Aspartate Aminotransferase (AST) activity was observed in animals treated with 500 μg of polypropylene. Tilapia fed polypropylene in the diet showed an increase in thrombocyte and total leukocyte counts, marked by a significant increase in the number of circulating lymphocytes. The results of the somatic study revealed a significant increase in the stomach, liver and heart of tilapia fed with the polymer. Increase in the number of Gram-negative microorganisms and decrease in mesophilic aerobic microorganisms were observed in fish fed with the polymer. A dose-response effect was observed in these analyses. However, tilapia fed polypropylene showed deleterious effects resulting from the daily ingestion of this polymer, resulting in systemic inflammatory disorders and changes in the intestinal microbiota.Item Análises epidemiológica e espacial da Covid-19 no estado do Piauí(Universidade Brasil, 2021) Macedo, Glauber Bezerra; Tim, Carla Roberta; Garcia, Lívia AssisThe emergence of a new coronavirus in humans, first diagnosed in 2019, has many deaths and serious survival and psychosocial consequences. Through statistical tools and techniques associated with geographic technologies, this ecological, analytical and exploratory study is being developed, whose general objective is to carry out epidemiological and spatial analyzes of the distribution of confirmed cases and deaths from Coronavirus 2019 disease (Coronavirus Disease 2019 - COVID-19), in the year 2020, in the state of Piauí, Brazil. The variables listed are being assigned via the IBGE and SESAPI database. All confirmed cases and deaths with COVID-19 infection that were reported in 2020 in that state were included in the study. In the epidemiological analyzes descriptive statistics were carried out and in the spatial analyses, maps are being constructed using geoprocessing techniques, through the statistical analysis of Moran Global and Local. Preliminary results showed that, in 2020, 143,179 confirmed cases and 2,840 deaths caused by COVID-19 were reported in Piauí. A higher percentage of cases was observed in relation to females, young adults, and deaths in elderly, males, with chronic diseases. The capital Piauiense led the number of cases and deaths from the disease, probably due to the high population density. However, when considering the incidence and mortality coefficients of COVID-19, the highest rates in the state were considered in the municipalities of União and Água Branca, respectively. The spatial analysis of the cases showed clusters of high-high pattern of cases of the disease in the metropolitan region of Teresina, the region between Rios and the region of Tabuleiros do Alto do Parnaíba. A high-high cluster for mortality was verified in fillings in the region of Entre Rios and Vale do Sambito. The analyzes performed provided the visualization of spatial clusters and an identification of vulnerable areas, resulting in information that was not visualized working only with tabular data.Item Síntese, determinação estrutural, análise dos orbitais naturais de ligação e estudo espectroscópico vibracional e eletrônico do composto de coordenação BIS (Dietilditiocarbamato) Ferro(II) [Fe(DDTC)2].(Universidade Brasil, 2023) Télles Zepeda, Claudio Andrés; Pessoa, Rodrigo SávioWe performed the synthesis, computational molecular modeling and vibrational/electronic spectroscopic analysis of the coordination complex Iron(II) Bis(Diethyldithiocarbamate) [Fe(DDTC)2]. The optimization of the molecular structure was performed using Density Functional Theory with the functional B3LYP and basis set 6-311G(d,p). The experimental FT-IR and Raman spectra of the complex were recorded in the range 4000 – 0 cm-1, in order to correlate them with the calculated spectra. Most of the DFT calculated frequencies were found to agree with the experimental results. In order to investigate the internal electronic mobility of the complex, we performed the natural bond orbital analysis (NBO), which provides information regarding intramolecular charge transfer interactions that result from the overlapping of bonding and antibonding orbitals, as well as information about the electronic distribution between the HOMO and LUMO orbitals due to charge transfers. We also correlated the calculated and experimental UV-Vis spectra in order to investigate the configurations of several excited states of the complex that involve intra-ligand transitions. The results corroborate the existence of several Ligand to Metal and and Metal to Ligand charge transfer transitions, as well as metal-centered d-d transitions.Item Uso da Ozonioterapia em fungos causadores de Onicomicoses: estudo in vitro(Universidade Brasil, 2024) Del Castilo, Denise Vivianni Ferreira; Assis, Lívia; Tim, Carla Roberta: Onychomycosis is a common fungal infection of the nails, predominantly caused by dermatophytes such as Trichophyton rubrum (T. rubrum) and Microsporum gypseum (M. gypseum) and is a notoriously difficult condition to treat. Thus, the objective of the present study was to evaluate and compare, in vitro, the effectiveness of different times of ozone therapy on the main fungi that cause onychomycosis. Dermatophyte fungi T. rubrum (ATCC 28188) and M. gypseum (ATCC 24102) were incubated at 28° C for 14 days. Subsequently, the fungi were divided into 9 experimental groups according to the experimental time: Control Group (CG): the fungi were cultivated and did not receive any treatment; Cultivated fungi and received ozone therapy for a time of 2 min (G2”); 4 min (G4”); 6 min (G6”); 8 min (G8”); 10 min (G10”); 12 min (G12”); 14 min (G14”) and 16 min (G16”). The ozone concentration used was 2 µg/mL, oxygen flow of 1/4 L/min and applied dosages of 157, 314, 451, 628, 785, 943, 1100 and 1257 mg/m2, respectively. The main results show that the use of topical ozone therapy was effective in reducing the germination percentage of T. rubrum and M. gypseum in all experimental periods, presenting complete eradication with a treatment time of 6 min for T. rubrum and 14 min for M. gypseum. In conclusion, ozone therapy used topically, with emphasis on the treatment time of 6 min for T. rubrum (628 mg/m2) and 14 min (1257 mg/m2) for M. gypseum, promoted antifungal action on the main dermatophytes responsible for critical complications of onychomycosis, and may be proposed as a adjuvant in dermatological treatments.