Mestrado
URI permanente desta comunidadehttps://repositorioacademico.universidadebrasil.edu.br/handle/123456789/30
Navegar
2 resultados
Resultados da Pesquisa
Item Plasma rico em plaquetas (PRP) e sua associação com Ozonioterapia de volume controlado no rejuvenescimento facial: estudo piloto(Universidade Brasil, 2023) Camargo, Carla Lúcia de; Garcia, Lívia AssisSkin aging is a complex biological process, resulting from a combination of intrinsic and extrinsic factors which causes progressive structural and functional changes, as well as changes in the appearance of the skin, especially in photo-exposed areas. Platelet Rich Plasma (PRP) and ozone therapy (OT) have been suggested in clinical practice as promising and adjuvant therapies, however, the evidence is limited for their recommendations. Thus, the aim of the present study was to evaluate and compare the safety and efficacy of PRP in combination with volume-controlled OT in facial aging. To achieve this goal, a single-center prospective pilot study was conducted. Female participants, aged 40 to 60 years, were randomized into 2 groups: PRP Group (PRP): participants that underwent PRP applications; PRP and ozone therapy group (PRPOT): participants that underwent PRP applications associated with ozone therapy. Interventions were performed using the facial intradermal technique in 42 pre established points, totaling 4 sessions with an interval of 15 days between them. PRP was performed with the first centrifugation at 200 g for 10 min and the second at 400 g for 10 min. Volume-controlled OT was added to the PRP at a concentration of 30 µg/mL in a 1:1 ratio. For assessment and reassessment, analyses were performed using photographic records, assessment of frontal, periorbital, nasolabial and marionette wrinkles (Wrinkle Assessment Scale - WAS), self-esteem assessment (Brazilian Version of Rosenberg's Self-Esteem Scale) and assessment of patient satisfaction (FACE -Q). The results show that, at the end of the treatment, the PRP and PRPOT groups had a lower score for frontal and periorbital wrinkles assessed in the WAS and overall, an improvement in self-esteem and an increase in the satisfaction score with the treatment. However, the PRPOT had a lower score for globalwrinkles and higher levels of treatment satisfaction compared to the PRP. Thus, it canbe suggested that the PRP protocol performed in the present study, as well as its association with volume-controlled OT, proved to be safe and potentially promising modalities in the treatment of facial aging.Item Avaliação dos efeitos fototérmico do laser de diodo λ1470 nm na pele em modelo experimental de ratos.(Universidade Brasil, 2024) Godoi, Silvana Aparecida Girão de; Assis, Lívia; Tim, Carla RobertaThe subdermal high-power diode laser is a therapy that has been frequently used as a treatment for skin aging. However, there is a need for studies to verify morphological and molecular changes in the skin triggered by this light technology. Thus, the objective of the present study was to evaluate the photothermal effects of diode laser wavelength (λ) 1470 nm on the skin of rats. 20 male Wistar rats were used, randomized into 2 groups: placebo laser (LP): treatment with subdermal laser turned off; active laser (LA): subdermal laser treatment was used. For therapy, high-power diode laser equipment was used (λ = 1470 nm; P = 2 W; beam area = 240 μm; beam divergence in rad: 0.227; continuous mode), applied in 5 subdermal vectors in the region of the animal's back in an area of 24 cm2 depositing an average of energy of 85 J/cm2, in a single session and the tissue was evaluated 15 days after the intervention. To evaluate the effects of the treatment, histological, morphometric analyzes and immunoexpression of transforming growth factor beta (TGF-β) and vascular endothelial growth factor (VEGF) were performed. The results demonstrated that active laser animals showed a better arrangement of collagen fiber bands and an increase in the thickness of the dermis and the number of vessels. Furthermore, animals treated with active laser showed an increased immunoexpression of TGF-β and VEGF compared to placebo. Thus, we can conclude that the subdermal high-power diode laser proves to be a promising option in aesthetic dermatology, as it was capable of increasing vascularization and the expression of factors that enhance skin rejuvenation.