Bioengenharia
URI permanente para esta coleçãohttps://repositorioacademico.universidadebrasil.edu.br/handle/123456789/31
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Resultados da Pesquisa
Item Ensaio clínico cego e randomizado para avaliação de dois protocolos de Fotobiomodulação para a prevenção das complicações orais em pacientes transplantados de medula óssea(Universidade Brasil, 2021) Marski, Roberta Silveira da Silva; Nunez, Silvia CristinaBone marrow transplantation (BMT) or hematopoietic cell transplantation requires high doses of chemotherapy in patients who will undergo HSCT (Hematopoietic Stem Cell Transplantation), this chemotherapy regimen causes the destruction of cells with a high mitotic index leading to damage to the oral and gastric mucosa called Mucositis. The aim of this study was to investigate the efficacy of Photobiomodulation (PBM) in the prevention of oral complications in hematopoietic transplant patients applying PBM daily and comparing it to the application every other day, totalizing 4 weekly applications from the beginning of conditioning to neutrophilic engraftment (bone marrow engraftment) in gender-independent, halogen and/or haploidentical transplant recipients. The volunteers were randomly divided into 2 groups: Daily Laser Group (DLG) P=13; LG4 (4x a week) P=17. All groups were evaluated daily by a trained nursing staff., from the beginning of conditioning D-7 to D+21, the results were cataloged and analyzed in a blind, longitudinal study, according to the WHO scale for evaluation of oral mucositis and pain degree (VAS scale). The groups were submitted to low power laser treatment (Therapy XT-DMC, São Carlos, Brazil) with a wavelength of 660nm, Power of 100mW, exposure time of 20 s delivering 2J per point throughout the oral cavity. Data related to xerostomia, odynophagia and degree of mucositis were analyzed over 21 days and the data were compared statistically using the Mann-Whitney test. The statistical comparison results for xerostomia (D+8 p=0.4434), odynophagia (D+8 p=0.8560) and mucositis (D+8 p=0.7285) showed no significant differences at any time during the study. According to the results, the PBM protocol on alternate days is as efficient as the daily application for the prevention of oral complications in patients who underwent HSCT.Item Avaliação da fototerapia com diferentes comprimentos de onda no tratamento da Alopécia androgenética(Universidade Brasil, 2024) SILVA, Leandro Ferreira da; BAPTISTA, AlessandraAndrogenetic alopecia (AGA) is a hair dysfunction that promotes the transformation of terminal hairs into vellus hairs and consequent baldness. Phototherapy (FT) uses light, usually laser or LED, to stimulate, heal and/or regenerate damaged tissues and has been identified as a safe and promising resource for the treatment of AGA. The purpose of this study is to compare different wavelengths in the treatment of AGA. 10 volunteers were selected, randomly divided into 2 groups: Red Light Group (GLV, n=5) and Blue Light Group (GLA, n=5). The groups received point irradiation (4J/point), respectively, with the Venus equipment (MMOptics, São Carlos, Brazil), GLV (l= 660nm, P= 100 mW, for 40 s) and GLA (l= 440 nm, P = 150 mW, for 26.6 s). The interventions were carried out once a week, for 90 days, totaling 12 treatment sessions. The emergence of new hairs was analyzed by comparing the photographic record before any intervention (T1) and at the end of treatment (T2). The relationship between vellus threads and terminal threads was analyzed by trichoscopy with polarized light, before and at the end of treatment. A specific quality of life assessment questionnaire for androgenetic alopecia (Women's Androgenetic Alopecia Quality of Life Questionnaire -WAA-QoL) before and after the end of the interventions. The results showed that both red light and blue light, in the parameters tested in this study, led to an increase in the number of terminal strands after treatment (p< 0.05), which allowed a reduction in the central parting of the treated hair. The evaluation of the WAA-QoL questionnaire showed a lower percentage of responses with a higher degree of dissatisfaction after both treatments. Therefore, we can conclude that the use of phototherapy is an effective therapeutic resource in the treatment of AGA with red or blue light, in the parameters tested in this study.Item Ensaio clínico cego e randomizado para avaliação de dois protocolos de fotobiomodulação para a prevenção das complicações orais em pacientes transplantados de medula óssea(Universidade Brasil, 2021) Marski, Roberta Silveira da Silva; Nuñez, Silvia CristinaBone marrow transplantation (BMT) or hematopoietic cell transplantation requires high doses of chemotherapy in patients who will undergo HSCT (Hematopoietic Stem Cell Transplantation), this chemotherapy regimen causes the destruction of cells with a high mitotic index leading to damage to the oral and gastric mucosa called Mucositis. The aim of this study was to investigate the efficacy of Photobiomodulation (PBM) in the prevention of oral complications in hematopoietic transplant patients applying PBM daily and comparing it to the application every other day, totalizing 4 weekly applications from the beginning of conditioning to neutrophilic engraftment (bone marrow engraftment) in gender-independent, halogen and/or haploidentical transplant recipients. The volunteers were randomly divided into 2 groups: Daily Laser Group (DLG) P=13; LG4 (4x a week) P=17. All groups were evaluated daily by a trained nursing staff., from the beginning of conditioning D-7 to D+21, the results were cataloged and analyzed in a blind, longitudinal study, according to the WHO scale for evaluation of oral mucositis and pain degree (VAS scale). The groups were submitted to low power laser treatment (Therapy XT-DMC, São Carlos, Brazil) with a wavelength of 660nm, Power of 100mW, exposure time of 20 s delivering 2J per point throughout the oral cavity. Data related to xerostomia, odynophagia and degree of mucositis were analyzed over 21 days and the data were compared statistically using the Mann-Whitney test. The statistical comparison results for xerostomia (D+8 p=0.4434), odynophagia (D+8 p=0.8560) and mucositis (D+8 p=0.7285) showed no significant differences at any time during the study. According to the results, the PBM protocol on alternate days is as efficient as the daily application for the prevention of oral complications in patients who underwent HSCT.