Abordagens inovadoras no reparo de feridas com óleo ozonizado e terapia por fotobiomodulação

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2024

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Universidade Brasil

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Hard-to-heal wounds present significant challenges in their therapeutic context due to the presence of pathogenic microorganisms and associated infections, thus resulting in delays for the tissue-healing process. The present study aimed to carry out a clinical trial to identify the microbial agent present in hard-to-heal wounds on the lower limbs, assess the antimicrobial effects of ozonated oil and examine the benefits of photobiomodulation combined with ozonated oil in the treatment of those wounds. Then we examined the antimicrobial kinetics of ozonated oil on microorganisms found in wounds by an in vitro study. For this study, some commercial ozonated sunflower oil was used as well as the LED photobiomodulation therapy, 660 nm, 30 seconds, punctual 2 cm away on the wound bed and on the margins in contact with the skin, 120 mW, 3.6 J per point. The procedure was performed three times a week, for a period of 12 weeks. The clinical results evidenced a significant healing of injuries treated with ozonated oil and photobiomodulation, evidenced by a reduction in traces of infection, presence of granulation tissue, wound area reduction and, in some cases, full wound closure. Among the microorganisms identified are Klebsiella sp., Staphylococcus epidermidis and Escherichia coli, all proved resistant to the antibiotics tested. The results obtained in vitro revealed that the ozonated oil was effective in reducing and eliminating colony-forming units in all microorganisms tested when subjected to concentrations deemed low, ranging from 1.6% to 12.5%, demonstrating antibacterial activity. In conclusion, ozonized oil, associated with photobiomodulation therapy, demonstrated efficacy in the treatment of wounds that are difficult to repair. However, new clinical trials are necessary to establish more improved treatment protocols.

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Ferida crônica, Óleo ozonizado, Terapia de fotobiomodulação, Atividade antimicrobiana, Resistência antimicrobiana

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