Monografias, Dissertações e Teses
URI permanente desta comunidadehttps://repositorioacademico.universidadebrasil.edu.br/handle/123456789/1
Navegar
2 resultados
Resultados da Pesquisa
Item Fotobiomodulação como coadjuvante no tratamento da lesão pulmonar aguda decorrente de sepse(Universidade Brasil, 2020) Dantas, Emanuelle; Garcia, Lívia Assis; Tim, Carla RobertaSepsis is a common condition associated with high mortality and, for many who survive, long-term morbidity. It is defined as infection with organ dysfunction, with the lung being one of Organs most affected organs. Acute lung injury (ALI) is a serious and serious disease, characterized by infiltrations of pulmonary inflammatory cells, diffuse alveolar damage, in addition to loss of the alveolar epithelium, together with edema and changes in gas exchange. During the rehabilitation period, there is a growing concern to modulate these processes in order to prevent complications and favor the patient's functional recovery. The therapeutic verification of the applications of photobiomodulation therapies (PBM) through lasers and LEDs) in the clinical treatment of inflammatory diseases is currently well known, however the mechanisms of action triggered by these resources and their use in clinical practice for the treatment of APL due to sepsis still remains incipient. Thus, this thesis aimed to provide an understanding of the current evidence on the importance of PBM in the treatment of respiratory disorders and its possible applicability in APL due to sepsis, as well as to evaluate and compare in vivo the PBM response through laser and LEDs on the LPA in rats. A qualitative, descriptive and exploratory narrative literature review was carried out and an experimental study using male Wistar rats, allocated in 3 (three) experimental groups: Sepsis control (CS); laser treatment (LASER); LED treatment (LED). Irradiations in the red wavelength (630 nm) were applied at three points (anterior region of the trachea and in the ventral regions of the chest, bilaterally) 1 and 24 hours after surgery. Based on all verified evidence and results observed in this study, it is inferred that PBM through laser and LED can be proposed as a support for conventional medical therapy in the treatment of APL arising from sepsis, due to the potential to mitigate the inflammatory condition, prevent the progression of the lung parenchyma lesion and, consequently, reduce the recovery time of the patient with ALI due to sepsis.Item Influência da Terapia por Fotobiomodulação no tratamento de condições inflamatórias pulmonares e seu impacto sobre o Covid-19(Universidade Brasil, 2021) Macedo, Daniela Bezerra; Tim, Carla Roberta; Garcia, Lívia AssisToday we are facing a pandemic that continually causes high rates of deaths and catastrophic and countless economic and psychosocial consequences. Thus, this period requires a rapid search for viable procedures that can allow us to use safe and noninvasive clinical tools as prophylactic or even adjuvant methods in the treatment of COVID-19, thus constituting an important challenge to the medical clinic. Evidence shows that photobiomodulation therapy (PBMT) is shown to attenuate the inflammatory process and reduce respiratory disorders similar to acute lung injury (ALI), complications associated with infections, such as that caused by the new Coronavirus (SARS-CoV-2). Thus, the aim of this study was to evaluate the influence of laser PBMT on infrared length in the treatment of ALI, one of the main critical complications of COVID-19 infection, in an experimental model of rats. Twenty-four male Wistar rats were randomly allocated into three experimental groups (n = 8): Control (CG); LPA (LPA); LASER-treated LPA (LPAL). For the treatment, a laser equipment (808 nm; 30 mw; 1.8 J) was applied at three points (anterior region of the trachea and in the venereal regions of the thorax bilaterally) in the period of 1 and 24 hours after lpa induction. Descriptive histopathological analysis, lung injury score, analysis of the number of inflammatory cells, interleukin 1 β (IL-1β) and interleukin 10 levels (IL-10) were performed for treatment evaluation. In the results, it was possible to observe that the treatment reduced inflammatory infiltrates, there was thickening of the alveolar septum and the pulmonary injury score when compared to the LPA group. In addition, laser PBMT showed lower immunoexpression of IL-1β, however, it did not alter the levels of pulmonary IL-10. Thus, it can be concluded with this experimental study that infrared laser PBMT was efficient in attenuating ALI, one of the main complications of COVID-19, since it was able to reduce the inflammatory process, as well as increase the production of anti-inflammatory cytokines.