Influência da Terapia por Fotobiomodulação no tratamento de condições inflamatórias pulmonares e seu impacto sobre o Covid-19
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Data
2021
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Universidade Brasil
Resumo
Today we are facing a pandemic that continually causes high rates of deaths and
catastrophic and countless economic and psychosocial consequences. Thus, this
period requires a rapid search for viable procedures that can allow us to use safe and
noninvasive clinical tools as prophylactic or even adjuvant methods in the treatment of
COVID-19, thus constituting an important challenge to the medical clinic. Evidence
shows that photobiomodulation therapy (PBMT) is shown to attenuate the
inflammatory process and reduce respiratory disorders similar to acute lung injury
(ALI), complications associated with infections, such as that caused by the new
Coronavirus (SARS-CoV-2). Thus, the aim of this study was to evaluate the influence
of laser PBMT on infrared length in the treatment of ALI, one of the main critical
complications of COVID-19 infection, in an experimental model of rats. Twenty-four
male Wistar rats were randomly allocated into three experimental groups (n = 8):
Control (CG); LPA (LPA); LASER-treated LPA (LPAL). For the treatment, a laser
equipment (808 nm; 30 mw; 1.8 J) was applied at three points (anterior region of the
trachea and in the venereal regions of the thorax bilaterally) in the period of 1 and 24
hours after lpa induction. Descriptive histopathological analysis, lung injury score,
analysis of the number of inflammatory cells, interleukin 1 β (IL-1β) and interleukin 10
levels (IL-10) were performed for treatment evaluation. In the results, it was possible
to observe that the treatment reduced inflammatory infiltrates, there was thickening of
the alveolar septum and the pulmonary injury score when compared to the LPA group.
In addition, laser PBMT showed lower immunoexpression of IL-1β, however, it did not
alter the levels of pulmonary IL-10. Thus, it can be concluded with this experimental
study that infrared laser PBMT was efficient in attenuating ALI, one of the main
complications of COVID-19, since it was able to reduce the inflammatory process, as
well as increase the production of anti-inflammatory cytokines.
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Palavras-chave
Fotobiomodulação, Fototerapia, Laser de baixa intensidade, Lesão pulmonar aguda, Covid-19