Monografias, Dissertações e Teses
URI permanente desta comunidadehttps://repositorioacademico.universidadebrasil.edu.br/handle/123456789/1
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Resultados da Pesquisa
Item Estudo da composição bioquímica de unhas para o diagnóstico de Diabetes Mellitus por Espectroscopia Raman(Universidade Brasil, 2021) Veras, Juscélia Maria de Moura Feitosa; Fávero, Priscila Pereira; Garcia, Lívia Assis; Martin, Airton AbrahãoThe growth of Diabetes Mellitus (DM) is a public health problem with greater prevalence in developing countries. The estimated prevalence of diabetes in people aged 20-79 years has increased from 151 million to 463 million today, with a total forecast of 700 million diabetics by 2045. Hence the importance of an early, non invasive, practical and low-cost diagnosis for DM detection and monitoring. Type II diabetes mellitus (DM2) gradually changes the intrinsic material properties of tissues and their structural integrity, and prolonged hyperglycemia can cause chronic damage to the quality of these tissues. No technique is available to clinically assess altered tissue quality in diabetic patients. However, recent studies suggest that the quality of the nail plate has great potential to assess the secondary complications of DM. Thus, this study aimed to determine the biochemical characteristics of nails of individuals with DM2 through confocal Raman spectroscopy, in addition to identifying the spectral signatures and new DM2 markers in nails. This study is a multicenter clinical study (Universidade Brasil - SP and Fundação Municipal de Saúde de Teresina/PI), comparative, randomized and instrumental with a qualitative approach. For the research, 30 healthy volunteers and 30 DM2 were selected. The collection and evaluation of fragments in the distal region of the nail was carried out. The results obtained demonstrated alterations in different biochemical components, such as: proteins, lipids, amino acids, advanced glycation end products, in addition to alterations in the disulfide bridges, which are important in the stabilization of keratin in the nails. Therefore, due to the possibility of acquiring such information through the evaluation of nails, a simple and easy-to-acquire material, this becomes an important material for analysis, allowing DM and its complications to be detected quickly. In addition, the study also demonstrated that the assessment of nails by confocal Raman spectroscopy is an important technique, which, together with the assessment of nails, can become an important tool in the diagnosis and follow-up of diabetic patients.Item Aplicação da Espectroscopia Raman Confocal para rastreamento de um produto cosmético pela unha humana no tratamento da síndrome de unhas frágeis(Universidade Brasil, 2020) Feitosa, Mara Regina Pereira Viana Damasceno; Fávero, Priscila Pereira; Martin, Airton AbrahãoFragile nail syndrome has a high prevalence in medical offices and adherence to treatment with fortifying products is still a challenge, since, in Brazilian culture, there is a custom of fading nails weekly. In this context, the present work aims to apply Confocal Raman Spectroscopy to determine the ability of a nail-strengthening product to permeate through enamel with one and two layers and reach the nail, allowing the treatment of syndrome of fragile nails on enameled nails. For this, 05 (five)participants were selected, between men and women, aged 19 to 55 years. The permeation of the product was measured in virgin nail, with one and two layers of enamel. The product was deposited after one hour of enamel application and permeation was measured after one hour of product deposition. It was observed that the product permeates enamel and penetrates the nail up to approximately 18 μm. It was also possible to detect the presence of the main components of this product at approximately 18 μm depth in the nail. Therefore, the product crosses the enamel layer and permeates the nail facilitating the treatment in enameled nails. This result becomes promising because it provides for greater adherence of patients with pathology to treatment. The permeation in virgin nail is shown five times higher than the enameled nail with one and two layers, which proves a good permeation of the product. In this way, Raman Confocal Spectroscopy will bring subsidies to the cosmetic industry for sustaining the ability of a product to permeate the enamel layer and treat the nail.Item Estudo da composição bioquímica de unhas para o diagnóstico de diabetes mellitus por Espectroscopia Raman(Universidade Brasil, 2021) Veras, Juscélia Maria de Moura Feitosa; Garcia, Lívia Assis; Martin, Airton Abrahão; Fávero, Priscila PereiraThe growth of Diabetes Mellitus (DM) is a public health problem with greater prevalence in developing countries. The estimated prevalence of diabetes in people aged 20-79 years has increased from 151 million to 463 million today, with a total forecast of 700 million diabetics by 2045. Hence the importance of an early, noninvasive, practical and low-cost diagnosis for DM detection and monitoring. Type II diabetes mellitus (DM2) gradually changes the intrinsic material properties of tissues and their structural integrity, and prolonged hyperglycemia can cause chronic damage to the quality of these tissues. No technique is available to clinically assess altered tissue quality in diabetic patients. However, recent studies suggest that the quality of the nail plate has great potential to assess the secondary complications of DM. Thus, this study aimed to determine the biochemical characteristics of nails of individuals with DM2 through confocal Raman spectroscopy, in addition to identifying the spectral signatures and new DM2 markers in nails. This study is a multicenter clinical study (Universidade Brasil - SP and Fundação Municipal de Saúde de Teresina/PI), comparative, randomized and instrumental with a qualitative approach. For the research, 30 healthy volunteers and 30 DM2 were selected. The collection and evaluation of fragments in the distal region of the nail was carried out. The results obtained demonstrated alterations in different biochemical components, such as: proteins, lipids, amino acids, advanced glycation end products, in addition to alterations in the disulfide bridges, which are important in the stabilization of keratin in the nails. Therefore, due to the possibility of acquiring such information through the evaluation of nails, a simple and easy-to-acquire material, this becomes an important material for analysis, allowing DM and its complications to be detected quickly. In addition, the study also demonstrated that the assessment of nails by confocal Raman spectroscopy is an important technique, which, together with the assessment of nails, can become an important tool in the diagnosis and follow-up of diabetic patients.