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URI permanente desta comunidadehttps://repositorioacademico.universidadebrasil.edu.br/handle/123456789/30
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Resultados da Pesquisa
Item Plasma rico em plaquetas: investigação da efetividade de diferentes protocolos para aplicação em pé diabético(Universidade Brasil, 2020) Cruz, Cecília Penha Dall'orto; Tim, Carla Roberta; Assis, LíviaDiabetes mellitus (DM) is characterized as a metabolic disorder of persistent hyperglycemia. Diabetic foot is one of the first complications identified in diabetic patients and causes major negative manifestations in their quality of life. These wounds are prone to infection, and when, moderate or severe, they suffer some level of limb amputation. Platelet-rich Plasma (PRP) is a biological product produced from an autologous blood centrifugation process, allowing plasma extraction with a concentration of three to five times higher than that of platelets without basal blood. In this perspective, this study aimed at a systematic review to assess the effectiveness of different PRP recovery protocols for wound treatment and to verify the feasibility of PRP recovery protocols by varying the strength / speed and the centrifugation time. For this purpose, a search was performed in the articles of the Virtual Health Library (VHL) with the descriptors in English and Portuguese “chronic ulcers, Platelet-rich plasma, Deep Soft Tissue Repair, Chronic Wounds, Wound Healing, Regenerative Medicine, Therapeutics and wound healing. Use a combination of descriptors as a search strategy. The publication period was delimited between the years 2010 to 2019. Other productions that were not included in the scientific article category were excluded, such as thesis, dissertations as well as inconclusive work, case reports, review of narrative literature and study on animals. 66 articles were selected, after exclusion, only 13 composite articles or corpus of the study. In 61.5 % of the studies, a PRP autologous gel application was used; and 38.4 % opted for injecting PRP, either subcutaneously or intradermally. Total of 13 studies analyzed, all proven that the PRP assist in the healing and tissue regeneration process. In 23 % of the studies analyzed there was an investigation of the pain variable, with improvements in it and in the patient's quality of life. Clinical trials continue to be of great importance for the case in question, as well as the analysis of systematic literature for recruiting information and increasing the occurrence of subjects. PRP has a great optional therapeutic potential in the treatment and healing process of chronic ulcers. Therefore, the second study aimed to evaluate the effectiveness of the reproduction of two PRP recovery protocols, varying strength / speed and centrifugation time. Twenty trained volunteers were recruited, with platelet count within the reference range 150 - 450.10/³ uL. Two different centrifuges were used to prepare the PRP: 1) CE1161 digital laboratory model centrifuge, adjustable speed - 0 to 5000 rpm with a radius of 14 cm and fixed rotor; with 10 patients; 2) Kasvi digital mod. Ce800, adjustable speed from 100 to 4000 rpm with a radius of 14 cm and variable angle, with 10 patients. The present study found that the preparation of the PRP using the highest force / speed and the centrifugation time, promoting the concentration of coatings statistically higher when compared to the protocol of lower force / speed. It was not possible to reproduce the protocols in different centrifuges. The results pointed out beyond the force of gravity and the centrifugation time, or the rotor angle can also influence the preparation of the PRP.Item Plasma rico em plaquetas (PRP) e sua associação com Ozonioterapia de volume controlado no rejuvenescimento facial: estudo piloto(Universidade Brasil, 2023) Camargo, Carla Lúcia de; Garcia, Lívia AssisSkin aging is a complex biological process, resulting from a combination of intrinsic and extrinsic factors which causes progressive structural and functional changes, as well as changes in the appearance of the skin, especially in photo-exposed areas. Platelet Rich Plasma (PRP) and ozone therapy (OT) have been suggested in clinical practice as promising and adjuvant therapies, however, the evidence is limited for their recommendations. Thus, the aim of the present study was to evaluate and compare the safety and efficacy of PRP in combination with volume-controlled OT in facial aging. To achieve this goal, a single-center prospective pilot study was conducted. Female participants, aged 40 to 60 years, were randomized into 2 groups: PRP Group (PRP): participants that underwent PRP applications; PRP and ozone therapy group (PRPOT): participants that underwent PRP applications associated with ozone therapy. Interventions were performed using the facial intradermal technique in 42 pre established points, totaling 4 sessions with an interval of 15 days between them. PRP was performed with the first centrifugation at 200 g for 10 min and the second at 400 g for 10 min. Volume-controlled OT was added to the PRP at a concentration of 30 µg/mL in a 1:1 ratio. For assessment and reassessment, analyses were performed using photographic records, assessment of frontal, periorbital, nasolabial and marionette wrinkles (Wrinkle Assessment Scale - WAS), self-esteem assessment (Brazilian Version of Rosenberg's Self-Esteem Scale) and assessment of patient satisfaction (FACE -Q). The results show that, at the end of the treatment, the PRP and PRPOT groups had a lower score for frontal and periorbital wrinkles assessed in the WAS and overall, an improvement in self-esteem and an increase in the satisfaction score with the treatment. However, the PRPOT had a lower score for globalwrinkles and higher levels of treatment satisfaction compared to the PRP. Thus, it canbe suggested that the PRP protocol performed in the present study, as well as its association with volume-controlled OT, proved to be safe and potentially promising modalities in the treatment of facial aging.