Atividade antibiofilme de nanofibras de policaprolactona/polietilenoglicol/gelatinametacrilamida

Abstract

One of the biggest challenges in relation to the healing of chronic wounds is the microbial infection caused by biofilms resistant to antibiotics that can increase the cost in public health. In this study we report the antibacterial effect of the union of the three polymeric biomaterials such as polycaprolactone (PCL), polyethylene glycol (PEG) and gelatin-methacrylamide (GelMA), by electrospinning. PCL:PEG:GelMA was first modified with glycidyltrimethyl ammonium chloride (GTMAC) in an attempt to add a quaternary amine group. We characterize the morphology and chemical structure of the fibers. The biofilms of Escherichia coli, Staphylococcus aureus and Staphylococcus epidermidis evaluated the antibacterial activity of scaffolds. The addition of this group of quaternary amines increased the positive charge available to react with the negatively charged bacterial cells, causing further disruption in the bacterial cells and therefore increasing their antibacterial activity.