Atividade bactericida e reparação tecidual de arcabouços à base de Policaprolactona: uma revisão sistemática

Abstract

The structure and function of the skin is often damaged by factors such as chronic wounds, ulcers, surgical incisions, ruptures, and burns. Depending on the severity and size of the lesion, there is loss of water, blood, and bacterial infections, requiring the use of antibiotics to treat these lesions, but it can result in increasing drug resistance in bacterial populations. Therefore, the development of polycaprolactone-based materials to reduce the use of antibiotics and avoid resistance, the application of this biodegradable polymer is attractive. Thus, the objective of this study was to review the literature on the use of PCL-based nanofibers in tissue engineering, to evaluate their bactericidal and tissue repair activity. Randomized clinical trials published between 2016 and 2021 were included, in English and Portuguese on tissue engineering, using a PCL-based framework alone or in combination with other material where the databases used were: PubMed, ScienceDirect, SciELO and LILASCS, where it resulted in 15 articles selected after the inclusion and exclusion criteria. The results found indicated that Polycaprolactone (PCL) was used as a base in all scaffolds, being associated with other biomaterials (chitosan, collagen, silver ions, gelatin, among others), in which it was observed that in all of them a good repair was obtained. tissue, but not all biomaterials had a bactericidal action. It is concluded that, despite all the studies showing good tissue repair, it was observed that the bactericidal action did not happen or was not the focus of the selected research, however an observed characteristic is that the tests in humans are rarely performed, therefore, a study aimed at human applications is necessary to observe the bactericidal activity in these PCL based scaffolds.