Efeitos da fotobiomodulação associada ou não ao Biopolímero de Fibrina Heterólogo no processo de reparo tecidual de lesões cutâneas de ratos diabéticos
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Data
2021
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Editor
Universidade Brasil
Resumo
INTRODUCTION: Diabetes mellitus is a general heterogeneous term that classifies
metabolic disorders caused by increased glucose levels (hyperglycemia). Among the
therapeutic modalities researched in order to accelerate tissue repair, LED
photobiomodulation therapy and heterologous fibrin biopolymer stand out.
PURPOSE: To evaluate the effects of LED photobiomodulation therapy associated or
not with heterologous fibrin biopolymer in the tissue repair process of skin lesions in
diabetic rats. METHODOLOGY: Forty-eight adult female Wistar rats (Rattus
norvegicus albinus), 60 days old, weighing 230±20 g, from the vivarium of the State
University of Piauí, were used. The animals were randomly divided into 4 distinct
groups (control group, heterologous fibrin biopolymer group, LED photobiomodulation
therapy group, LED photobiomodulation therapy group associated with heterologous
fibrin biopolymer), which were treated in two experimental periods (7 and 14 days).
Diabetes was induced by the administration of an aqueous solution of 2% alloxan
and the animals had their blood glucose assessed using a glucometer and clinical
symptoms. The animals underwent two surgical procedures, in the dorsal and
cervical regions, the first by means of a skin punch, an area of 2 cm²; and the second
a linear lesion measuring 3 cm, in the cervical region. Healing analysis was
performed by calculating the contraction of the wound area and evaluating the
traction force. RESULTS: The treatments with LED photobiomodulation therapy and
heterologous fibrin biopolymer, used alone or in combination, indicated the
stimulation of the repair process. The heterologous fibrin biopolymer group showed
similar results to the LED photobiomodulation therapy group in wound regression, but
showed better healing resistance, suggesting that the LED group has both repair
qualities. The LED photobiomodulation therapy group associated with heterologous
fibrin biopolymer showed better results in resistance and regression when compared
to the heterologous fibrin biopolymer and LED photobiomodulation therapy groups,
statistically closer to the control group. CONCLUSION: Based on the findings, it was
observed that treatments with LED, BFH or LED associated with BFH acted
satisfactorily, favoring the improvement in the tissue repair process, suggesting that
these treatments, isolated or associated, were effective in stimulating the healing
process in diabetic rats.
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Palavras-chave
Diabetes mellitus, Feridas, Biopolímero de fibrina heterólogo, Terapia por Fotobiomodulação, LED