Bioengenharia
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Navegando Bioengenharia por Assunto "Bioengenharia"
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Item Estudo do microrelevo cutâneo após o uso da dermaplanagem por meio da fotogrametria digital tridimensional(Universidade Brasil, 2021) Ventura, Danielle Bastos da Silva; Frade-Barros, Amanda FarageThe skin surface is a barrier and can selectively communicate with the internal biological environment and the external environment, it is not flat and contains several straight grooves that can be classified according to depth, and therefore, these conditions that define its micro relief are related to its exchanges and its breathing, so the photogrammetric analysis instruments allow its amplification, making it possible and necessary to describe them. Dermaplaning is a technique used in qualified aesthetic protocols, facial rejuvenation and the treatment of atrophic scars, based on the concept of physically removing the superficial layers of the skin by dragging a blade of sterile, disposable butter from a scalpel. The three-dimensional photogrammetry analysis instruments are modern resources of current tissue bioengineering and allow a form of tissue enlargement in a precise and non-invasive way. Two dermaplaning intervals with 21-day intervals were performed in women between 18 and 38 years old, divided into 2 groups (control n = 21, test n = 21) with complaints of skin texture alteration. The effectiveness of the treatment was evaluated using three-dimensional digital photogrammetry and photothermographic imaging before and after the preparations. The group showed decreased oiliness, local hydration and increased count of elastic and collagen fibers, as well as surface pigmentation, through arbitrary measures provided by the equipment. This study was of fundamental importance to verify, in addition to the changes in the biotype, that there were topographic changes in the cutaneous microrelief after the use of dermaplaning and showed that the technique is a possible effective dermatological or aesthetic therapy to improve the microrelief, but it is necessary its post-procedure skin management.Item Luz UV-C na descontaminação de diferentes superfícies(Universidade Brasil, 2021) Soares, Roseane Débora Barbosa; Baptista, AlessandraItem A suplementação de vitamina C inibe hiperativação de células de Leucemia Mielóide Crônica induzidas por Lipopolysaccarídeo: envolvimento da sinalização purinérgica(Universidade Brasil, 2021) Pires, Daniela Alves; Vieira, Rodolfo de PaulaChronic myeloid leukemia (CML) is a myeloproliferative neoplasm, characterized by overproduction of white blood cells, with the patients presenting anemia, fatigue, infections, bleeding, and other problems. Thus, an important goal for CML patients is to prevent infections and inhibit the exacerbation of inflammatory processes. In this context, the present study investigated whether vitamin C could inhibit hyperinflammatory activation of K562 cells induced by LPS and whether purinergic signaling is involved in such response. Two doses of vitamin C were used (5 µg/mL and 10 µg/mL) for 2 hours prior LPS (10ng/mL) for 22 hours in K-562 cells (3x105 cells/mL/well). The results demonstrated that both doses of vitamin C significantly reduced LPS-induced the release of IL-6 (5 µg/mL, p<0.01 and 10µg/mL p<0.01) and TNF-alpha (5 µg/mL, p<0.01 and 10µg/mL p<0.01). In contrast, both doses of vitamin C induced the release of the anti-inflammatory cytokine IL-10 (5 µg/mL, p<0.01 and 10µg/mL p<0.01). In addition, 10µg/mL of vitamin C induced the release of klotho(10µg/mL p<0.01), an anti-aging and antiinflammatory protein. Importantly, vitamin C (5 µg/mL, p<0.01 and 10µg/mL p<0.01) reduced ATP release and accumulation in the extracellular milieu as well as reduce the expression at mRNA levels of P2X7 receptor, suggesting a possible mechanism of action. Therefore, we conclude that vitamin C inhibits hyperinflammatory state induced by LPS in K-562 cells involving purinergic signaling.